Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 85417
Gene Symbol: CCNB3
CCNB3
0.100 Biomarker group BEFREE BCOR-CCNB3 sarcomas showed swirling fascicular growth. 31647130 2020
Entrez Id: 54880
Gene Symbol: BCOR
BCOR
0.100 Biomarker group BEFREE BCOR-CCNB3 sarcomas showed swirling fascicular growth. 31647130 2020
Entrez Id: 54880
Gene Symbol: BCOR
BCOR
0.100 Biomarker group BEFREE Fine-Needle Aspiration Features of BCOR-CCNB3 Sarcoma. 31679010 2020
Entrez Id: 6597
Gene Symbol: SMARCA4
SMARCA4
0.100 GeneticVariation group BEFREE Newly discovered uterine sarcoma subtypes include high-grade endometrial stromal sarcomas with BCOR genetic abnormalities, fibrosarcoma-like uterine sarcomas with NTRK rearrangements and COL1A-PDGFRB fusions, as well as undifferentiated uterine sarcomas with SMARCA4 mutations. 31846533 2020
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.100 Biomarker group BEFREE Herein, we report the clinical, histopathologic, and molecular findings of a germline DICER1-associated ovarian sarcoma in a 5-year-old female, a somatic DICER1-associated metastatic peritoneal sarcoma in a 16-year-old female, and a somatic DICER1-associated primary intracranial sarcoma in a 4-year-old male. 31537896 2020
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.100 Biomarker group BEFREE Several central nervous system (CNS) manifestations have also been defined, including metastases of PPB to the cerebrum, pituitary blastoma, pineoblastoma, ciliary body medulloepithelioma, and most recently primary DICER1-associated CNS sarcomas and ETMR-like infantile cerebellar embryonal tumor. 30953130 2020
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 GeneticVariation group BEFREE Ewing sarcoma is the prototype of round cell sarcoma whereas in CIC sarcomas, focal pleomorphism and epithelioid morphology can predominate. 31802230 2020
Entrez Id: 54880
Gene Symbol: BCOR
BCOR
0.100 Biomarker group BEFREE The tumor showed an undifferentiated phenotype, including negativity for cytokeratin, although it was immunoreactive to BCOR and MUC4, and was initially suspected as BCOR-associated sarcoma. 31385070 2020
Entrez Id: 54880
Gene Symbol: BCOR
BCOR
0.100 Biomarker group BEFREE BCOR sarcomas often exhibit a spindled neoplastic cell population. 31802230 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker group BEFREE This enabled successful estimation of TP53 penetrance for three LFS cancer types: breast (BR), sarcoma (SA), and others (OT), from 186 pediatric sarcoma families collected at MD Anderson Cancer Center. 31719101 2020
Entrez Id: 85417
Gene Symbol: CCNB3
CCNB3
0.100 GeneticVariation group BEFREE Fine-Needle Aspiration Features of BCOR-CCNB3 Sarcoma. 31679010 2020
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.100 Biomarker group BEFREE Primitive round- or spindle-cell EWSR1-negative undifferentiated sarcomas harboring CIC-DUX4 gene fusion are the most common form of Ewing-like sarcomas. 28474974 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation group BEFREE Dual-energy spectral CT characteristics in surgically resected lung adenocarcinoma: comparison between Kirsten rat sarcoma viral oncogene mutations and epidermal growth factor receptor mutations. 31783917 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.100 Biomarker group BEFREE EWSR1-PATZ1 is a rare fusion partnering in sarcoma, with few cases reported in the literature. 31189996 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.100 GeneticVariation group BEFREE Fibroblast growth factor receptor (FGFR)3 and phosphatidylinositol‑4,5‑bisphosphate 3‑kinase, catalytic subunit alpha (PIK3CA) mutations are found in various types of cancer, such as urinary bladder cancer, human papillomavirus‑positive tonsillar and base of the tongue squamous cell carcinoma, breast cancer and some childhood sarcomas. 31638167 2019
Entrez Id: 100288687
Gene Symbol: DUX4
DUX4
0.100 Biomarker group BEFREE CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs. 31329165 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 AlteredExpression group BEFREE Exposure of sarcoma and PDX ovarian carcinoma cells to [pazopanib + entinostat] caused a prolonged activation of ERBB1 and transient/prolonged activations of ERBB2, c-KIT, and c-MET, in a cell-specific fashion. 31380285 2019
Entrez Id: 100288687
Gene Symbol: DUX4
DUX4
0.100 Biomarker group BEFREE CIC-DUX4 fusion sarcoma is a round cell tumor now considered an entity separate from Ewing sarcoma with a more aggressive clinical course, occurrence in older age, and predilection to soft tissues. 30633925 2019
Entrez Id: 6597
Gene Symbol: SMARCA4
SMARCA4
0.100 Biomarker group BEFREE Imaging features of SMARCA4-deficient thoracic sarcomas: a multi-centric study of 21 patients. 30762113 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.100 GeneticVariation group BEFREE The current version now includes PEComatous tumors, myoepithelial tumors, and pulmonary myxoid sarcomas with <i>EWSR1-CREB1</i> translocation as new disease entities. 30775024 2019
Entrez Id: 54880
Gene Symbol: BCOR
BCOR
0.100 GeneticVariation group BEFREE Accumulating evidence suggests that internal tandem duplications (ITD) of BCOR are oncogenic drivers in a subset of pediatric sarcomas and rare adult tumors. 30380541 2019
Entrez Id: 85417
Gene Symbol: CCNB3
CCNB3
0.100 Biomarker group BEFREE BCOR-CCNB3 fusion sarcoma is cyclin B3-positive, usually occurs in bone or soft tissue of children, and may mimic a poorly differentiated synovial sarcoma. 30633925 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.100 Biomarker group BEFREE All follicular dendritic cell sarcomas were negative for ALK by IHC (D5F3 and 5A4). 29877921 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.100 GeneticVariation group BEFREE A pathological review and a molecular analysis (CTNNB1 gene mutation) were performed (National re-reading network of sarcomas-RRePS). 31016642 2019
Entrez Id: 85417
Gene Symbol: CCNB3
CCNB3
0.100 Biomarker group BEFREE More than 50% of cases stained positive for SATB2 and Pax8, raising the hypothesis of a potential use of these markers in the identification of BCOR-CCNB3 positive undifferentiated/unclassified sarcomas. 28420319 2019