|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further survival analysis with log-rank test demonstrated that the patients with significant IGHV gene mutations showed a trend towards poor survival.The mutation rate of the IGHV variant region may be determined to assess the prognosis and overall survival time of MCL patients.
|
31145313 |
2019 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Clinically, the nonnodal MCL subset is notable for leukemic presentation, indolent behavior, and association with hypermutated IGHV and lack of SOX11 expression, which differentiates it from the conventional nodal MCL.
|
31808882 |
2019 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both CLL and MCL include 2 major molecular subtypes that seem to derive from antigen-experienced CD5<sup>+</sup> B cells that retain a naive or memory-like epigenetic signature and carry a variable load of immunoglobulin heavy-chain variable region somatic mutations from truly unmutated to highly mutated, respectively.
|
29666114 |
2018 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Eight MCL samples (33%) carried TERTp mutations, two homozygous and six heterozygous (seven C228T and one C250T), which directly correlated with higher TERT transcription, mitochondrial DNA copy number, and IGHV mutational status in MCL neoplastic cells.TERTp mutations were not found in oLN.
|
26852175 |
2016 |
|
LOC102724971
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunogenotyping showed specific IGHV gene usage partly resembling MCL.
|
24891323 |
2014 |
|
LOC102724971
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data show that mantle cell lymphoma cell lines resemble the IGHV and IGLV usage of mantle cell lymphoma, and foster the hypothesis that light chain stereotypy might be under-recognized.
|
23245212 |
2013 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A gene set enrichment analysis showed that MCL with high and low IGHV mutations were enriched in memory and naive B-cell signatures, respectively.
|
22915760 |
2012 |
|
LOC102724971
|
0.100 |
Biomarker
|
disease |
BEFREE |
We applied high-resolution methylation microarrays (27,578 CpG sites) to assess the global DNA methylation profiles in 20 MCL (10 each with high/low proliferation signature) and 30 CLL (15 poor-prognostic IGHV unmutated subset #1 and 15 good-prognostic IGHV mutated subset #4) samples.
|
22374828 |
2012 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Non-nodal leukaemic MCLs display a peculiar clinical presentation, with distinctive biological features, such as mutated IGHV and a transcriptional profile lacking tumour invasion properties, that might contribute to the absence of nodal involvement and to the less aggressive clinical course.
|
22150124 |
2012 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined 807 productive IGHV-IGHD-IGHJ gene rearrangements from mantle cell lymphoma (MCL) cases, by far the largest series to date.
|
21791422 |
2011 |
|
LOC102724971
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, older and more recent studies have demonstrated that MCL is characterized by a highly distinctive immunoglobulin gene repertoire with remarkable predominance of the IGHV3-21 and IGHV4-34 genes; restricted associations of IGHV, IGHD and IGHJ genes, culminating in the creation of quasi-identical ("stereotyped") heavy complementarity-determining region 3 sequences in roughly 10% of cases; and, very precisely targeted and, probably, functionally driven somatic hypermutation, ranging from minimal (in most cases) to pronounced.
|
21946621 |
2011 |
|
LOC102724971
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, we defined nonnodal presentation, predominantly hypermutated IGVH, lack of genomic complexity, and absence of SOX11 expression as qualities of a specific subtype of iMCL with excellent outcomes that might be managed more conservatively than cMCL.
|
20124476 |
2010 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MCL cases utilising the IGHV3-21 gene display less chromosomal alterations than MCLs using other IGHV genes and in addition, gains in 15q and losses in 9p were not observed in any of these cases.
|
18452063 |
2008 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Somatic mutation analysis of the immunoglobulin heavy chain variable region (VH) gene in case 1 found a relatively higher mutation frequency (5.0%), which was not definitive to rule out MCL.
|
17300675 |
2007 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We find no evidence against a diagnosis of MCL in the nonnodal group and suggest that mutated IgVH genes may help identify patients with indolent disease.
|
12609845 |
2003 |