| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | Accordingly, most MCL cell lines proved sensitive to the specific MCL-1 inhibitor S63845, and MCL-1 inhibition also proved efficacious in an MCL xenograft model. | 31772331 | 2020 | ||||
|
0.090 | Biomarker | disease | BEFREE | Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal <i>In Vivo</i> in Relapsed Mantle Cell Lymphoma. | 31004002 | 2019 | ||||
|
0.090 | Biomarker | disease | BEFREE | Reactive oxygen species mediate cancer stem-like cells and determine bortezomib sensitivity via Mcl-1 and Zeb-1 in mantle cell lymphoma. | 30251692 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | Apoptosis was NOXA-dependent and correlated with the NOXA/MCL1 ratio, highlighting the importance of the NOXA/MCL1 balance for effective cell death induction in MCL. | 28295185 | 2017 | ||||
|
0.090 | Biomarker | disease | BEFREE | These data suggest that lipidoid nanoparticles siRNA therapy targeting Mcl-1 has potential as a new treatment modality for mantle cell lymphoma and many other cancers that overexpress Mcl-1. | 27022142 | 2016 | ||||
|
0.090 | Biomarker | disease | BEFREE | B-PAC-1 sponsored apoptosis in MCL cell lines (30-73%) via caspase-3 and PARP cleavages accompanied by loss of Mcl-1 and IAPs including XIAP while Zn substantially abrogated B-PAC-1-driven apoptosis (18-36%). | 26658105 | 2016 | ||||
|
0.090 | Biomarker | disease | BEFREE | Further analysis demonstrated that the anti-apoptotic Bcl-2 family member Mcl-1 plays a central role in regulation of MCL survival. | 23580240 | 2013 | ||||
|
0.090 | Biomarker | disease | BEFREE | P276-00 causes time and dose dependent increase in the sub G1 population as early as from 24 h. Reverse transcription PCR studies provide evidence that P276-00 treatment down regulated transcription of antiapoptotic protein Mcl-1 which is a potential pathogenic protein for MCL. | 23075291 | 2012 | ||||
|
0.090 | Biomarker | disease | BEFREE | Here we show that GX15-070 induced apoptosis in vitro in MCL cell lines and primary cells from patients with MCL by releasing Bak from Mcl-1 and Bcl-X(L) at short incubation times and low micromolar doses. | 17227835 | 2007 |