Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE The SOX11 negative leukemic non-nodal mantle cell lymphomas were also negative by RNAscope. 31296581 2020
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 AlteredExpression disease BEFREE The expression of SOX11 mRNA was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and the relationship of survival with SOX11 mRNA and MIPI in MCL patients was evaluated. 31646825 2020
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 AlteredExpression disease BEFREE Interestingly, our data revealed a potential inverse relationship between phosphorylated Y705 STAT3 and SOX11 expression in MCL cell lines, primary tumors, and patient-derived xenografts. 30530749 2019
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE In summary, SOX11-negative MCL is characterized by more frequent leukemic non-nodal disease, classic morphology, more frequent expression of CD23 and CD200, and a lower Ki67 index. 30768440 2019
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE SOX11-positive MCL showed a significant higher microvascular development than negative tumours (median MVA = 14.5 × 10<sup>-3</sup> versus 5.0 × 10<sup>-3</sup> P < 0.001; median MVD = 18.6/μm<sup>2</sup> versus 14.2/μm<sup>2</sup> , P = 0.021). 31173643 2019
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE In this study, we evaluated the diagnostic accuracy of SOX11 immunohistochemistry for the diagnosis of MCL using a meta-analysis. 31714947 2019
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 AlteredExpression disease BEFREE Recently, SOX11 has been suggested to be a diagnostic marker and oncogene because of its significant expression in mantle cell lymphoma (MCL). 30221780 2019
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 AlteredExpression disease BEFREE SOX11 is a transcription factor that plays an important role in mantle cell lymphoma development. 30922366 2019
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 AlteredExpression disease BEFREE Heterogeneity in the clinical course of MCL-indolent vs aggressive-is further delineated by a correlation with the mutational status of the variable region of immunoglobulin heavy chain, methylation status, and SOX-11 expression. 30963600 2019
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 AlteredExpression disease BEFREE Clinically, the nonnodal MCL subset is notable for leukemic presentation, indolent behavior, and association with hypermutated IGHV and lack of SOX11 expression, which differentiates it from the conventional nodal MCL. 31808882 2019
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 AlteredExpression disease BEFREE A database search showed that SOX11, a crucial transcription factor in MCL, is the putative target of miR-223. 29158064 2018
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 GeneticVariation disease BEFREE We have measured MRD level in follow-up samples from 27 patients diagnosed with MCL using the molecular markers: t(11;14), IGH rearrangement and SOX11 expression. 29520657 2018
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 AlteredExpression disease BEFREE We report here that overexpression of SOX11 in B cells promotes BCR signaling and a disease phenotype that mimics human MCL. 29615403 2018
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE Upregulated SOX11 may be a good prognostic factor in MCL patients. 29771407 2018
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE Cyclin D1 and SOX11 only stain the central portion that represents MCL and LEF-1 stains the periphery that represents CLL/SLL. 28109040 2018
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE SOX11 is a relevant element in the pathogenesis of MCL and has been instrumental to identify two distinct clinicobiological subtypes of this tumor. 29738333 2018
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 AlteredExpression disease BEFREE We conducted immunohistochemical staining of C-MYC, Programmed cell death ligand 1 (PD-L1), CD8, Ki-67, p53 and SRY (sex determining region Y) -11 (SOX11) to investigate their expression in 64 patients with MCL. 28626618 2017
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE In intravenous MCL xenograft models, SOX11<sup>+</sup> MCL cells display higher cell migration, invasion, and growth compared with SOX11-knockdown cells, and specific FAK and CXCR4 inhibitors impair SOX11-enhanced MCL engraftment in bone marrow. 28533307 2017
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE The absence of SOX-11 or a low Ki-67 may correlate with a more indolent form of MCL. 28699667 2017
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE To this end, since little data are available in the literature, four commercially available anti-SOX11 antibodies (two polyclonal and two monoclonal) were tested on 21 positive staging bone marrow (BM) biopsies from cyclin D1/SOX11-positive MCL patients (17 fixed in B5, 4 in 10% buffered formalin) and on 9 positive BM biopsies from leukemic non-nodal MCL patients. 27720733 2017
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE Recent data have revealed the potential oncogenic role of SOX11 in MCL biology, highlighting its implication in tumor aggressiveness and progression. 28466437 2017
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE Conclusively, our data suggest that SOX11 represents a useful prognostic marker in mantle cell lymphoma. 28429312 2017
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE An integrative epigenomic approach revealed 10,504 differentially methylated regions in regulatory elements marked by H3K27ac in MCL primary cases, including a distant enhancer showing de novo looping to the MCL oncogene SOX11. 27846393 2016
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 AlteredExpression disease BEFREE However, recent data show that the neural transcription factor SOX11 is a disease defining antigen and several involved signaling pathways have been pin-pointed, among others the Wnt/β-catenin pathway that is of importance for proliferation in MCL. 27430213 2016
Entrez Id: 6664
Gene Symbol: SOX11
SOX11
0.100 Biomarker disease BEFREE Among them, SOX11 has been found aberrantly expressed in most aggressive MCL patients, being considered a reliable biomarker in the pathology. 26998831 2016