Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 AlteredExpression disease BEFREE Overexpression of cyclin D2, which is rare in MCL, occurred more frequently in DLBCL (11 cases, 10.6%). 26985765 2016
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 GeneticVariation disease BEFREE The patient was transferred to our hospital, flow cytometry using additional markers showed that the clonal cells were CD200+(dim), CD148+(strong), and chromosome analysis revealed a complex karyotype, 47, XY, t(12;14)(p13;q32), +12, del(9p21), which indicated over-expression of CCND2, and immunostaining showed strong positivity of SOX11 further confirming the characteristics of CCND1-negtive MCL. 26261659 2015
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 GeneticVariation disease BEFREE In this issue of Blood, Salaverria et al report that more than half of Cyclin D1- (CCND1) negative SOX11-positive mantle cell lymphoma (MCL) had CCND2 gene rearrangement predominantly with immunoglobulin (IG) light chain genes.(1) 23429984 2013
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 GeneticVariation disease BEFREE CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma. 23255553 2013
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 GeneticVariation disease BEFREE CD5-positive, cyclinD1-negative mantle cell lymphoma with a translocation involving the CCND2 gene and the IGL locus. 21504716 2011
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 Biomarker disease BEFREE Small interfering RNAs targeting cyclin D1 and cyclin D2 enhance the cytotoxicity of chemotherapeutic agents in mantle cell lymphoma cell lines. 21745168 2011
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 AlteredExpression disease BEFREE In mantle-cell lymphoma, the t(11;14) translocation leads to overexpression of cyclin-D1, in addition to which cyclin-D1-negative mantle-cell lymphoma that overexpress cyclin-D2 or D3 have also been described. 20062012 2010
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 Biomarker disease BEFREE There are rare cyclin D1-negative cases of MCL overexpressing cyclin D2. 19783727 2009
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 AlteredExpression disease BEFREE Cyclin D2 and D3 mRNA levels were significantly higher in cyclin D1-negative mantle cell lymphoma than in conventional mantle cell lymphoma but the protein expression was not discriminative. 19880778 2009
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 GeneticVariation disease BEFREE We analyzed 4 cases of cycD2(+) mantle cell lymphoma with a translocation involving the CCND2 locus, and its differential diagnosis from 35 mature B-cell non-Hodgkin's lymphomas based on immunohistochemistry, quantitative RT-PCR and FISH analysis. 19608671 2009
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 AlteredExpression disease BEFREE In sum-mary, this study confirms frequent aberrant expression of cyclin D2 and D3 in t(11;14)-negative MCLs and shows a t(11;14)-independent expression of cy-clin D1 in 25% of present cases. 18391076 2008
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 Biomarker disease BEFREE Specific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2. 18685613 2008
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.100 AlteredExpression disease BEFREE Up-regulation of cyclin D2 or D3 may substitute for cyclin D1 in the pathogenesis of MCL. 16123218 2005