Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE Irinotecan (CPT-11) is chemotherapy used mainly in the metastatic colorectal cancer. 28393405 2018
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE Recently, the efficacy of combining CPT-11 and anti-epidermal growth factor receptor (EGFR) agents was confirmed in patients with KRAS wild-type metastatic colorectal cancer. 28711984 2017
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE Administration of CPT-11 plus BV to patients with mCRC achieved comparable efficacies with relatively lower toxicities compared with the results of previous studies using FOLFIRI plus BV as second-line therapy. 28213683 2017
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE Combination treatment with cetuximab and CPT-11 produces beneficial and synergistic effects in wild-type RAS metastatic colorectal cancer (mCRC) patients. 28656305 2017
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 GeneticVariation disease BEFREE A phase I study of UGT1A1 *28/*6 genotype-directed dosing of irinotecan (CPT-11) in Korean patients with metastatic colorectal cancer receiving FOLFIRI. 25427841 2015
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE We investigated the efficacy and safety of the combination of irinotecan (CPT-11) and S-1 (IRIS regimen) as a first-line treatment in patients with metastatic colorectal cancer. 22555197 2012
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 GeneticVariation disease BEFREE We investigated associations between polymorphisms in both miRNA-containing genomic regions (primary and precursor miRNA) and in genes related to miRNA biogenesis with clinical outcome in metastatic colorectal cancer (mCRC) patients treated with 5-fluorouracil and irinotecan (CPT-11). 20585341 2011
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE Recent findings have disclosed the role of UDP-glucuronosyltransferase (UGT) 1A1*28 on the haematological toxicity induced by irinotecan (CPT-11), a drug commonly used in the treatment of metastatic colorectal cancer (mCRC). 21892003 2011
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE The topoisomerase I inhibitor irinotecan (CPT-11) is worldwide approved for the treatment of metastatic colorectal cancer and undergoes extensive peripheral and tumoral metabolism. 20196838 2010
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE The monoclonal antibody (mAb) cetuximab showed intrinsic activity as a single agent in mCRC and was approved in combination with CPT-11 for patients who failed previous CPT-11-based treatment. 21474966 2010
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE To determine the dose-limiting toxicity (DLT), maximum tolerated dose, recommended dose (RD) and preliminary evidence of activity of escalating doses of irinotecan (CPT-11) fixed-dose-rate infusional gemcitabine (FDR-GMB) and bevacizumab in pretreated metastatic colorectal cancer (mCRC) patients. 20940716 2010
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE Irinotecan [Camptosar (CPT-11), Pfizer Pharmaceuticals, New York, USA] is one of the most effective chemotherapeutic agents in the treatment of metastatic colorectal cancer. 19770637 2009
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE Use of irinotecan (CPT-11) as second-line therapy for metastatic colorectal cancer has shown some promise in cases where 5-fluorouracil (5-FU) has failed. 18506996 2008
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 GeneticVariation disease BEFREE IFL [irinotecan (CPT-11), 5-fluorouracil (5-FU), and folinic acid] is one of the treatments for metastatic colorectal cancer. 17725105 2007
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE A pilot study on the safety of combining chrysin, a non-absorbable inducer of UGT1A1, and irinotecan (CPT-11) to treat metastatic colorectal cancer. 16003560 2006
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.100 Biomarker disease BEFREE Irinotecan (CPT-11) is a promising antitumor agent, recently approved for use in patients with metastatic colorectal cancer. 9466980 1998