Integrative analyses of genetic, methylation, and gene expression data identified consistent directions of associations across 12 CpG, five genes, and EOC risk, suggesting that methylation at these 12 CpG may influence EOC risk by regulating expression of these five genes, namely <i>MAPT, HOXB3, ABHD8, ARHGAP27</i>, and <i>SKAP1</i>.