Gene: ABCB1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE Colorectal cancer susceptibility: apparent gender-related modulation by ABCB1 gene polymorphisms. 25355168 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer. 16702732 2006
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 AlteredExpression disease BEFREE ABCB1 gene polymorphisms and expression of P-glycoprotein and long-term prognosis in colorectal cancer. 19192650 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer. 20533057 2010
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 Biomarker disease BEFREE P-Glycoprotein 1 Affects Chemoactivities of Resveratrol against Human Colorectal Cancer Cells. 31487863 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 AlteredExpression disease BEFREE MDR1 expression correlates with mutant p53 expression in colorectal cancer metastases. 8898977 1996
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer. 22396794 2012
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 Biomarker disease BEFREE AFP promoter-driven anti-MDR1 ribozymes reduced the IC(50) 30-fold for epirubicin in HCC cells, whereas human colorectal cancer cells were unaffected. 12297834 2002
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE Association between MDR1 C3435T polymorphism and colorectal cancer risk: A meta-analysis. 29390571 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE Association of ABCB1 genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis. 23746184 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE Associations of ABCB1 and XPC genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis in a Chinese population. 23803084 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE Carriers of the variant allele of MDR1 intron 3 had odds ratios (95% CI) of 0.97 (0.72-1.29) for developing adenomas, and 0.70 (0.41-1.21) for colorectal cancer, respectively, compared to homozygous wild type carriers. 19250544 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 Biomarker disease BEFREE Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp) encoded by the MDR1 gene, is a major obstacle to successful chemotherapy for colorectal cancer. 24901713 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE Collectively, the results of the present study suggest that there were no significant associations of ABCB1/MDR1 C3435T polymorphism with colorectal cancer observed for all comparison models. 23504525 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 PosttranslationalModification disease BEFREE COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer. 21296766 2011
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE Differences in ABCB1 (1236C>T) and ABCB1 (2677G>T/A) genotypes and T(1236) allele distribution between investigated populations indicate significant impact of these SNPs on risk of development of colorectal cancer. 19415305 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 AlteredExpression disease BEFREE Effect of ionizing radiation on transcription of colorectal cancer MDR1 gene of HCT-8 cells. 23608383 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans. 16800822 2006
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 AlteredExpression disease BEFREE Furthermore, studies of colorectal cancer specimens indicated that the expression of miR-26b and Pgp had inverse correlation. 30662808 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE Genotyping of ABCB1 variants can help to prevent severe adverse reactions to irinotecan-based treatments in colorectal cancer. 30213564 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE Genotyping of SNPs in the ABCB1 gene prior to chemotherapy administration could help reduce adverse reactions in colorectal cancer patients. 21142915 2010
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE However, a smoking and age-stratified analysis, revealed a statistically significant association between MDR1 genotypes and colorectal cancer in life-long non-smokers with an age > or =63 years (the median age in our sample). 17146660 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE In the present study, 146 Bulgarian patients with sporadic colorectal cancer and 160 healthy Bulgarian volunteers were evaluated for the two polymorphisms in MDR1. 17674045 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 GeneticVariation disease BEFREE In this study suggest that C3435T MDR1 polymorphism has an association with colorectal cancer. 20127181 2011
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.100 AlteredExpression disease BEFREE JJR reversed multidrug resistance and enhanced the sensitivity to chemotherapy, which could be attributed to the down-regulation of COX-2 in MDR1/P-gp-mediated MDR colorectal cancer after chemotherapy. 23543356 2014