Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | Biomarker | disease | BEFREE | These observations, coupled with both in vitro and in vivo studies reported here, suggest anthocyanin-enriched sweet potato P40 may protect against colorectal cancer by inducing cell-cycle arrest, antiproliferative, and apoptotic mechanisms. | 23784800 | 2013 | ||||
|
0.100 | Biomarker | disease | BEFREE | Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models. | 22579651 | 2012 | ||||
|
0.100 | Biomarker | disease | BEFREE | Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition. | 20413844 | 2010 | ||||
|
0.100 | Biomarker | disease | BEFREE | Importantly, activated Pak1 elicited phosphorylation of FAK at Ser-910 via an ERK-dependent pathway in colorectal cancer cell lines and clinical samples. | 20811717 | 2010 | ||||
|
0.100 | Biomarker | disease | BEFREE | Inhibition of the MEK/ERK pathway sensitized colorectal cancer cells to paclitaxel-induced apoptosis. | 19521235 | 2009 | ||||
|
0.100 | Biomarker | disease | BEFREE | These results indicate that KGF enhances the adhesion of colorectal cancer cells to type-IV collagen through ERK and FAK signaling pathways. | 17706640 | 2007 | ||||
|
0.100 | Biomarker | disease | BEFREE | The positive feedback loop between TOPK and ERK2 increases tumorigenesis properties of HCT116 colorectal cancer cells, and TOPK-regulated signaling may serve as a potential therapeutic target in colorectal cancer. | 17631144 | 2007 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Good correlation between H-ras expression levels and those of the upstream and downstream signaling proteins of EGFR, MEK and ERK was found, suggesting that H-ras may play a significant role in carcinogenesis of colorectal cancer. | 11605075 | 2001 |