Gene: MTCO2P12 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 AlteredExpression disease BEFREE This study sought to evaluate short-term treatment with COX-2 inhibitors and acute changes in colonic PGE2 levels as predictors of long-term efficacy in a genetic model of colorectal cancer. 31797003 2020
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 Biomarker disease BEFREE Therefore, the present study was designed to assess the prophylactic potentials of probiotics (Lactobacillus acidophilus and Lactobacillus rhamnosus GG) in conjunction with celecoxib, a selective cox-2 inhibitor in 1,2 dimethylhydrazine dihydrochloride (DMH)-induced experimental colon carcinogenesis, a well-established, well appreciated and widely used model for colorectal cancer that shares many similarities to human sporadic colorectal cancer with respect to response to some promotional and preventive agents. 30183370 2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 Biomarker disease BEFREE Inhibition of COX-2 and 5-LOX regulates the progression of colorectal cancer by promoting PTEN and suppressing PI3K/AKT pathway. 29339153 2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 Biomarker disease BEFREE c-Myb and its Effector COX-2 as an Indicator Associated with Prognosis and Therapeutic Outcome in Colorectal Cancer. 31205515 2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 Biomarker disease BEFREE Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis. 31614548 2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 AlteredExpression disease BEFREE Prognostic significance of EGFR and COX-2 expression in colorectal cancer and their association. A study in Greek population. 29552755 2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 AlteredExpression disease BEFREE The role of COX-2 expression, especially its posttranscriptional regulation in colorectal cancer, needs further elucidation. 30186819 2018
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 AlteredExpression disease BEFREE Patient databases also delineated the correlation of RIPK3 and COX-2 expression with colorectal cancer survival. 30012671 2018
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 Biomarker disease BEFREE Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer. 29229353 2018
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 AlteredExpression disease BEFREE The Impact of Dietary Polyphenols on COX-2 Expression in Colorectal Cancer. 29068698 2018
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 Biomarker disease BEFREE MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5. 28786533 2018
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 AlteredExpression disease BEFREE Feces COX-2 mRNA has a high sensitivity for detect colorectal cancer; combination with FOBT will be the best alternative. 28139497 2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 AlteredExpression disease BEFREE The inhibitory effect induced by RSVL on the COX-2 expression in human colorectal cancer was investigated. 28338176 2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 AlteredExpression disease BEFREE YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer. 29037225 2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 AlteredExpression disease BEFREE FosB transcription factor regulates COX-2 expression in colorectal cancer cells without affecting PGE2 expression. 28454270 2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 Biomarker disease BEFREE Colorectal cancer is characterized by aberrant Cyclooxigenase-2 (COX-2) and β-Catenin pathways. 28178650 2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 AlteredExpression disease BEFREE In cell lines, three colorectal cancer cell lines exhibited high expression of COX-2 and 5-LOX. 26707712 2016
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 GeneticVariation disease BEFREE The presence of the COX-2 -1195AA genotype may protect against risk of developing colorectal cancer. 25835114 2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 AlteredExpression disease BEFREE Normal colorectal mucosa and paired cancerous tissue from 60 patients with colorectal cancer was investigated for the levels of COX-2 mRNA by real-time quantitative Polymerase Chain Reaction (qPCR). 24383454 2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 GeneticVariation disease BEFREE This research evaluated risk of association of the SNPs, including genes for COX-2 (A/G transition at +202) and MMP-2 (C/T transition at-1306), with colorectal cancer in 125 patients and 125 healthy controls. 24998576 2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 GeneticVariation disease BEFREE Meta-analysis of the association between COX-2 polymorphisms and risk of colorectal cancer based on case-control studies. 24733273 2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 GeneticVariation disease BEFREE No significant liver cancer and colorectal cancer risk of COX-2 -765G/C polymorphism was found. 24969885 2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 AlteredExpression disease BEFREE These results imply that miR-1297 has the potential to provide a new approach to colorectal cancer therapy by directly inhibiting Cox-2 expression. 25422199 2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 Biomarker disease BEFREE Effects of Jianpi Jiedu Recipe on reversion of P-glycoprotein-mediated multidrug resistance through COX-2 pathway in colorectal cancer. 23543356 2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.100 GeneticVariation disease BEFREE Interactions between diet, lifestyle and IL10, IL1B, and PTGS2/COX-2 gene polymorphisms in relation to risk of colorectal cancer in a prospective Danish case-cohort study. 24194923 2013