Gene: PIK3CA ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 GeneticVariation disease BEFREE Lysine-specific demethylase 1 mediates AKT activity and promotes epithelial-mesenchymal transition in PIK3CA mutant colorectal cancer. 31704733 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE We have previously shown that compound-7g inhibits colorectal cancer cell proliferation and survival by inducing cell cycle arrest and PI3K/AKT/mTOR pathway blockage. 31357480 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE In short, COX-2 or 5-LOX deletion and its inhibitors enhanced activity of PTEN and suppressed cell and adenoma progression through PI3K/AKT pathway in colorectal cancer. 29339153 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE The PEAK1-PPP1R12B axis inhibits tumor growth and metastasis by regulating Grb2/PI3K/Akt signalling in colorectal cancer. 30472186 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE Anthocyanins Prevent and Inhibit Colorectal Cancer through PI3K/AKT/survivin Signaling Pathway. 31830892 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE Further, the role of PI3K/Akt/mTOR inhibitors alone and in combination with other chemotherapeutic drugs, in alleviating colorectal cancer is also discussed. 31215384 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 AlteredExpression disease BEFREE Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2. 31719636 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 GeneticVariation disease BEFREE Analysis of KRAS, NRAS, BRAF, and PIK3CA mutations could predict metastases in colorectal cancer: A preliminary study. 30085422 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer. 30623365 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE CCR7 high expression leads to cetuximab resistance by cross-talking with EGFR pathway in PI3K/AKT signals in colorectal cancer. 31815051 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 GeneticVariation disease BEFREE Fisetin could be used as a preventive agent plus an adjuvant with 5-FU for the treatment of PIK3CA-mutant colorectal cancer. 31018249 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE We selected MAPK- and PI3K-pathway inhibition in colorectal cancer as a model system to dissect out mechanisms of resistance. 30905967 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE FAT4 regulates the EMT and autophagy in colorectal cancer cells in part via the PI3K-AKT signaling axis. 30832706 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines. 30691487 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE H19 regulates PI3K-Akt signal pathway through a competing endogenous RNA network and predicts poor prognosis in colorectal cancer. 31164794 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 AlteredExpression disease BEFREE Previously, we showed that activation of PI3K/Akt/mTOR contributes to colorectal cancer growth and metastasis. 29666061 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE Assessment of PI3K/AKT/PTEN signaling pathway activity in colorectal cancer using quantum dot-conjugated antibodies. 29422975 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression. 29970122 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 AlteredExpression disease BEFREE The PI3K/AKT signaling pathway: Associations of miRNAs with dysregulated gene expression in colorectal cancer. 29068474 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE EYA1 promotes tumor angiogenesis by activating the PI3K pathway in colorectal cancer. 29496520 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE Although TANKYRASE (TNKS) inhibitors have been proposed as promising candidates, there are many colorectal cancer models that do not respond positively to TNKS inhibition <i>in vitro</i> and <i>in vivo</i> Therefore, a combinatorial therapeutic approach combining a TNKS inhibitor (G007-LK) with PI3K (BKM120) and EGFR (erlotinib) inhibitors in colorectal cancer was investigated. 29222171 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE Crocin synergistically enhances the antiproliferative activity of 5-flurouracil through Wnt/PI3K pathway in a mouse model of colitis-associated colorectal cancer. 30129057 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer. 29260353 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 GeneticVariation disease BEFREE Two recent retrospective studies strongly suggested that low-dose aspirin used (100 mg/d) after surgical resection of colorectal cancer with a PIK3CA mutation could act as a targeted therapy with a major protective effect on the risk of recurrence. 29402752 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 Biomarker disease BEFREE Role of Regulatory Oncogenic or Tumor Suppressor miRNAs of PI3K/AKT Signaling Axis in the Pathogenesis of Colorectal Cancer. 30636581 2018