Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 AlteredExpression disease BEFREE FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression. 30728402 2019
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 AlteredExpression disease BEFREE Melatonin may serve as a potential therapeutic option on its own, or in conjunction with 5-FU, in the treatment of patients with advanced or chemoresistant CRC.Melatonin inhibits the growth of 5-FU resistant colorectal cancer (CRC) cells through upregulation of miR-215-5p and a concomitant downregulation of TYMS. 30590435 2019
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 Biomarker disease BEFREE Floxuridine (5'-fluorodeoxyuridine, FUdR) acts as an inhibitor of DNA replication by binding to thymidylate synthase and is widely used to treat colorectal cancer. 30611569 2019
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 AlteredExpression disease BEFREE There was no correlation between ERCC1 mRNA expression, TYMS mRNA and clinicopathological features of colorectal cancer (P>0.05). 31423175 2019
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 Biomarker disease BEFREE Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating the thymidylate synthase. 30923017 2019
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 Biomarker disease BEFREE TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer. 31367274 2019
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 AlteredExpression disease BEFREE Notably, cobimetinib appeared to enhance the efficacy of 5-fluorouracil (5-FU) by decreasing TYMS expression, high expression of which is responsible for 5-FU resistance in colorectal cancer. 29794421 2018
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 GeneticVariation disease BEFREE XRCC3 Thr241Met and TYMS variable number tandem repeat polymorphisms are associated with time-to-metastasis in colorectal cancer. 29394274 2018
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 Biomarker disease BEFREE In this study, therefore, we examined the effect of a combination of TS silencing by an RNA interfering molecule, chemically synthesized short hairpin RNA against TS (shTS), and 5-FU on the growth of human colorectal cancer cell (DLD-1) both in vitro and in vivo. 27838412 2017
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 AlteredExpression disease BEFREE The Oncologist 2017;22:107-114Implications for Practice: This study finds that measurement of tumor levels of thymidylate synthase is not helpful in assigning specific adjuvant treatment for colorectal cancer. 27821793 2017
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 AlteredExpression disease BEFREE Long noncoding RNA XIST is a prognostic factor in colorectal cancer and inhibits 5-fluorouracil-induced cell cytotoxicity through promoting thymidylate synthase expression. 29137332 2017
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 Biomarker disease BEFREE MicroRNA-330 inhibited cell proliferation and enhanced chemosensitivity to 5-fluorouracil in colorectal cancer by directly targeting thymidylate synthase. 28521444 2017
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 Biomarker disease BEFREE In this study, primary tumors obtained from 1,129 patients with colorectal cancer were used to measure the mRNA expression levels of the following genes associated with the effects of standard chemotherapy for colorectal cancer: 5-fluorouracil (5-FU)-related thymidylate synthase (TYMS), dihydropyrimidine dehydrogenase (DPYD) and thymidine phosphorylase (TYMP); folate-related dihydrofolate reductase (DHFR), folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH); irinotecan-related topoisomerase I (TOP1); oxaliplatin-related excision repair cross-complementing 1 (ERCC1); biologic agent-related vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR). 26676887 2016
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 GeneticVariation disease BEFREE Long Survival and Severe Toxicity Under 5-Fluorouracil-Based Therapy in a Patient With Colorectal Cancer Who Harbors a Germline Codon-Stop Mutation in TYMS. 26210704 2015
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 Biomarker disease BEFREE MicroRNA-197 influences 5-fluorouracil resistance via thymidylate synthase in colorectal cancer. 26055341 2015
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 AlteredExpression disease BEFREE Overall, our data indicate that miR-203 enhances 5-FU chemosensitivity via the downregulation of TYMS in colorectal cancer and provide important insight into the mechanism of 5-FU resistance in colorectal cancer patients. 25482885 2015
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 GeneticVariation disease BEFREE A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS. 24647007 2015
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 Biomarker disease BEFREE Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in lung adenocarcinoma and colorectal cancer, and induce apoptosis in acute promyelocytic leukemia. 25335113 2015
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 GeneticVariation disease BEFREE Thymidylate synthase genetic polymorphisms and colorectal cancer risk: a meta-analysis. 24685603 2014
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 Biomarker disease BEFREE Thymidylate synthase is associated with risk of colorectal cancer but not with gastric cancer; however, heterozygous SL (2R/3R) polymorphism is associated with risk of gastric cancer; moreover, the 5' tandem repeat polymorphism of thymidylate synthase gene was an independent predictor of the clinical treatment. 24415354 2014
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 AlteredExpression disease BEFREE Role of topoisomerase I and thymidylate synthase expression in sporadic colorectal cancer: associations with clinicopathological and molecular features. 24332575 2014
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 AlteredExpression disease BEFREE These findings indicate a possible prognostic role of TYMS mRNA expression and highlight a cluster of genes associated with nodal metastases that warrant further investigation in a larger cohort of patients with colorectal cancer treated with 5-FU-based adjuvant chemotherapy. 25202077 2014
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 Biomarker disease BEFREE TYMS serves as a prognostic indicator to predict the lymph node metastasis in Chinese patients with colorectal cancer. 23810585 2013
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 AlteredExpression disease BEFREE Danenberg tumor profile method (DTP) was used in order to measure mRNA expression levels of thymidylate synthase (TYMS), dihydropyrimidine dehydrogenase (DPYD), and thymidine phosphorylase (TYMP) from 180 patients with colorectal cancer. 22593457 2012
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 GeneticVariation disease BEFREE Polymorphisms in the thymidylate synthase gene and risk of colorectal cancer. 23098521 2012