Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 80381
Gene Symbol: CD276
CD276
0.100 Biomarker disease BEFREE Serum miR-1301-3p, miR-335-5p, miR-28-5p, and their target B7-H3 may serve as novel biomarkers for colorectal cancer. 31424670 2020
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.100 Biomarker disease BEFREE The Prognostic and Predictive Value of Dihydropyrimidine Dehydrogenase-Related Indicators in Clinical Outcomes of Chemotherapy in Colorectal Cancer Patients: a Systematic Review and Meta-Analysis. 30519982 2020
Entrez Id: 8842
Gene Symbol: PROM1
PROM1
0.100 Biomarker disease BEFREE CD133: An emerging prognostic factor and therapeutic target in colorectal cancer. 31579983 2020
Entrez Id: 8842
Gene Symbol: PROM1
PROM1
0.100 Biomarker disease BEFREE The in vitro evaluation in terms of cellular uptake and cytotoxicity demonstrated that the CD133-PCAD-DMSN@DOX specifically targets HT29 as a CD133 overexpressed cancer cells confirmed by flow cytometry and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay. 31276199 2020
Entrez Id: 6657
Gene Symbol: SOX2
SOX2
0.100 Biomarker disease BEFREE Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2. 31641225 2020
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker disease BEFREE Th9 cells are subjected to PD-1/PD-L1-mediated inhibition and are capable of promoting CD8 T cell expansion through IL-9R in colorectal cancer. 31776089 2020
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE This study sought to evaluate short-term treatment with COX-2 inhibitors and acute changes in colonic PGE2 levels as predictors of long-term efficacy in a genetic model of colorectal cancer. 31797003 2020
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.100 Biomarker disease BEFREE Can [<sup>18</sup>F]F-FDG PET/CT be used to assess the pre-operative extent of peritoneal carcinomatosis in patients with colorectal cancer? 31642963 2020
Entrez Id: 6772
Gene Symbol: STAT1
STAT1
0.100 Biomarker disease BEFREE NMI promotes cell proliferation through TGFβ/Smad pathway by upregulating STAT1 in colorectal cancer. 31230364 2020
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.100 GeneticVariation disease BEFREE Current clinical guidelines recommend mutation analysis for select codons in KRAS and NRAS exons 2, 3, and 4 and BRAF V600E to guide therapy selection and prognostic stratification in advanced colorectal cancer. 31589789 2020
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE LY3214996 also exhibited synergistic combination benefit with a pan-RAF inhibitor in a KRAS-mutant colorectal cancer xenograft model. 31744895 2020
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE LL1 could be a promising therapeutic drug candidate for colorectal cancer by inhibiting the STAT3 activation. 31499589 2020
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 AlteredExpression disease BEFREE VEGF inhibitors don't contribute to increased D-dimer levels in colorectal cancer patients without VTE. 31662546 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE TP53 mutations drive colorectal cancer development, with missense mutations frequently leading to accumulation of abnormal TP53 protein. 31471586 2020
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Our results showed that miR-29a-5p was significantly upregulated and was accompanied by STAT3 activation in the colon tissues of CAC mouse and human colorectal cancer tissues, as compared with normal colon tissues. 31750910 2020
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.100 GeneticVariation disease BEFREE The epithelial cadherin -160C/A polymorphism is associated with decreased risk of colorectal cancer: a case-control study. 31625007 2020
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 AlteredExpression disease BEFREE This study sought to evaluate short-term treatment with COX-2 inhibitors and acute changes in colonic PGE2 levels as predictors of long-term efficacy in a genetic model of colorectal cancer. 31797003 2020
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 GeneticVariation disease BEFREE The polymorphism T309G (rs2279744) in the MDM2 gene was studied in patients with colorectal cancer (n=135) and healthy control subjects (n=145) using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. 31424672 2020
Entrez Id: 4360
Gene Symbol: MRC1
MRC1
0.100 GeneticVariation disease BEFREE Defects in MMR genes are known to be crucial for familial form of colorectal cancer but our findings suggest that specific genetic variations in MLH1 are important also in the individual predisposition to sporadic colon cancer. 31209889 2020
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.100 Biomarker disease BEFREE We aim to better understand MSH6 staining heterogeneity in colorectal cancer by comparative sequencing of different tumor areas for MMR and DNA polymerase mutations. 31783044 2020
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
0.100 Biomarker disease BEFREE Effect of PD98059 on chemotherapy in patients with colorectal cancer through ERK1/2 pathway. 31786845 2020
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation disease BEFREE Association of genetic variants with colorectal cancer in the extended MENA region: A systematic review. 31612830 2020
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker disease BEFREE Taken together, the ERBB3 kinase activity contributes to the outgrowth of ileal organoids and intestinal tumorigenesis, and the development of ERBB3 kinase inhibitors, including epidermal growth factor receptor family members, can be a potential way to target colorectal cancer. 31724799 2020
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
0.100 GeneticVariation disease BEFREE Colorectal cancer in Lynch syndrome associated with PMS2 and MSH6 mutations. 31845022 2020
Entrez Id: 406971
Gene Symbol: MIR195
MIR195
0.100 Biomarker disease BEFREE lncRNA SNHG1 cooperated with miR-497/miR-195-5p to modify epithelial-mesenchymal transition underlying colorectal cancer exacerbation. 31276207 2020