Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE Triple-negative breast cancer (TNBC) is an aggressive tumor subtype with an enriched CD44+/CD24- stem-like population. 26528725 2015
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE CD44 targeting hyaluronic acid coated lapatinib nanocrystals foster the efficacy against triple-negative breast cancer. 29129754 2018
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE CD44 receptor and mitochondria targeting hyaluronic acid-d-α-tocopherol succinate-(4-carboxybutyl)triphenyl phosphonium bromide (HA-TS-TPP)-based nanoparticles (NPs) were designed for the delivery of lapatinib (LPT) to triple-negative breast cancer (TNBC). 30566834 2019
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE Aptamer-guided siRNA-loaded nanomedicines for systemic gene silencing in CD-44 expressing murine triple-negative breast cancer model. 29277682 2018
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 GeneticVariation disease BEFREE Cancer-Associated MORC2-Mutant M276I Regulates an hnRNPM-Mediated CD44 Splicing Switch to Promote Invasion and Metastasis in Triple-Negative Breast Cancer. 30093560 2018
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression disease BEFREE Combination of using prodrug-modified cationic liposome nanocomplexes and a potentiating strategy via targeted co-delivery of gemcitabine and docetaxel for CD44-overexpressed triple negative breast cancer therapy. 28859899 2017
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression disease BEFREE CSCs with high epithelial specific antigen (ESA), high CD44 and low CD24 expression levels were derived from the TNBC cancer cells, MDA-MB-231 and MDA-MB-468. 31756533 2020
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression disease BEFREE Dihydrotestosterone regulates expression of CD44 via miR-328-3p in triple-negative breast cancer cells. 29964098 2018
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE Here we used the biomarker combination of ALDH and CD24/CD44 to sort four populations isolated from triple-negative breast cancer (TNBC) patient-derived xenografts, and performed whole-transcriptome sequencing on each population. 29471829 2018
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE Here, we found that PRL treatment of TNBC cells to significantly depletes the highly tumorigenic BCSC subpopulations CD44+/CD24- and ALDH+ and differentiate them to the least tumorigenic CD44-/CD24- and ALDH- phenotype with limited tumorsphere formation and self-renewal capacities. 30640712 2019
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE Here, we identify two T-ISC subsets within this population in triple negative breast cancer (TNBC) lines and dissociated primary breast cancer cultures: CD44(+) CD24(low+) subpopulation generates CD44(+) CD24(neg) progeny with reduced sphere formation and tumourigenicity. 23982961 2013
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression disease BEFREE Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer. 22937154 2012
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE Importantly, shNEAT1 reduced stem cell populations such as CD44+/CD24-, ALDH+, and SOX2+, implicating that NEAT1 was closely related to cancer stemness in TNBC. 30894512 2019
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE In summary, a CD44-targeted redox-triggered self-assembly nanosystem with magnetic enhanced EPR effects was developed for effective amplification of GA; it has potential to act as an effective carrier in drug delivery for chemotherapy of TNBC. 31674634 2019
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE In this work, we have fabricated a CD44/neuropilin dual receptor-targeting nanoparticulate system (tLyP-1-HT NPs) with endogenous or FDA approved components for treating metastatic triple negative breast cancer (TNBC). 28528300 2017
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression disease BEFREE Molecular mechanistic studies revealed that knockdown of DANCR was associated with increased binding of EZH2 on the promoters of CD44 and ABCG2, and concomitant reduction of expression of these genes suggested that they may be DANCR targets in TNBC. 28760736 2017
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression disease BEFREE Patients with triple negative breast cancer (ER–/PR–/HER2–) expressed CD44+CD49f+CD133/2+ in 9 of 9 normal adjacent tissue samples compared with 7 of 52 ER+ and/or Her2+ tumors (P < 0.001). 24008095 2013
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE Previous studies suggest that CD44+/CD24- cells, subpopulation of cancer stem cells with self-renewing and tumor-initiating capacities, are partly responsible for chemoresistance and therapeutic failure of triple negative breast cancer. 29190901 2017
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression disease BEFREE Supporting this genetic interaction, CD44 positively correlated with PD-L1 expression at the mRNA and protein levels in primary tumor samples of TNBC and NSCLC patients. 31722999 2020
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression disease BEFREE Taking this further, we report that P-RSK(S221/227) is present in primary TNBCs and correlates with P-YB-1(S102) as well as CD44. 22674792 2012
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression disease BEFREE Targeted delivery of CD44s-siRNA by ScFv overcomes de novo resistance to cetuximab in triple negative breast cancer. 29777999 2018
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE The formulated triple-functional nanomedicine is efficiently internalized by the CD44 expressing triple-negative breast cancer cells. 27654639 2017
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE The in vitro cellular uptake study and in vivo biodistribution and antitumor activity of the formulations were determined, all results showed that the complex micelle enhanced TNBC tumor cellular uptake and fast drug release due to the combined effect of magnet targeting, CD44 receptor-mediated internalization and redox/pH dual-responsive drug release. 30334478 2018
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE The present study detected the distribution of cancer stem cell markers cluster of differentiation (CD)44/CD24 and analyzed the clinical outcomes of different CD44/CD24 phenotypes in patients with TNBC. 29113223 2017
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker disease BEFREE These findings suggest that CD44(+)/CD24(-/low) breast cancer stem-like cells play an important role in the clinical behavior of triple-negative breast cancer and that development of therapeutic targets directed to breast cancer stem-like cells may lead to reduction in the aggressiveness of triple-negative breast cancers. 21835433 2012