Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Our results demonstrate the heterogeneity of MGAs, and that MGAs associated with TNBC, but not necessarily pure MGAs, are genetically advanced, clonal, and neoplastic lesions harbouring recurrent mutations in TP53 and/or other cancer genes, supporting the notion that a subset of MGAs and AMGAs may constitute non-obligate precursors of TNBCs. 26806567 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Genomic analysis of TNBC has revealed large-scale transcriptional, mutational, and copy number heterogeneity, without any frequently recurrent mutations, other than TP53. 28205193 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Triple-negative breast cancer (TNBC) patients had the highest incidence of TP53 (58%) and the lowest incidence of PIK3CA (9%) mutations. 27806348 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 29367998 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Taken together, all findings suggest that HR deficiency profile encompassed by BRCA mutation and high HRD score could predict response to platinum, even to other DNA-damage inducing agents. p53 family members and molecular subtypes of TNBC are also important alternative considerations for predicting platinum response based on the preclinical trials. 28494179 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant. 28235006 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE When p53 is positive in triple-negative breast cancer, we could expect poor survival, prompting aggressive or alternative treatment. 19304743 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Gain-of-function mutations in TP53 are a frequent occurrence in TNBC and have been demonstrated to repress apoptosis and up-regulate cell cycle progression. 25788226 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Genes with high frequency mutation rates such as MUC4 and TP53 were common to both racial populations, however genes that were less frequently mutated differed between the races suggesting that those cause the more aggressive nature of TNBC in AA women. 30366040 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Primary mouse mammary epithelial cells (mMEC) with defined genetic features were used to delineate the combined action of RB and/or p53 in the genesis of TNBC. 25602521 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE This study investigates the prognostic value of immunohistochemically detected p53 in TNBC patients who received adjuvant chemotherapy. 30527200 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. 25330770 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE Within the triple-negative breast cancer subset, cell lines with a p53 mutation and increased p53 expression were more sensitive to the cytotoxic and proapoptotic effects of ENMD-2076 exposure than cell lines with decreased p53 expression. 23136197 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE We performed p53 immunohistochemistry (IHC), nCounter mRNA expression assay, and DNA sequencing to determine the relationship between <i>TP53</i> alteration and clinical outcomes of TNBC patients. 26910472 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE The intron 3 16 bp duplication polymorphism of p53 (rs17878362) is not associated with increased risk of developing triple-negative breast cancer. 30430302 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE In this review, we highlight important signaling pathways regulated by WWOX and p53 that are related to estrogen receptor signaling, epithelial-to-mesenchymal transition, and genomic instability and how they impact BLBC and TNBC development. 31075076 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE The relationship of p16 expression with Ki-67 and its association with the status of p53 in TNBC patients have not been well characterized. 24560018 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE The aim of the current study was to investigate the possible synergism between dendrosomal nanocurcumin (DNC) and exogenously delivered p53 in producing anticancer effects on a TNBC cell line. 29753810 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE However, patients with TNBC showed p53 protein overexpression as determined by PLA-qPCR and western blotting (p<0.0001). 28393224 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Finally, this study showed that low and continuous exposure of H<sub>2</sub>S serves as a novel, selective and effective strategy in harnessing TNBC oncogenic profile through cGMP dependent and independent pathways where alterations of cell cycle regulatory proteins such as TP53 and c-Myc was observed. 30081213 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Here, we determined that combined inactivation of murine Rb and p53 in diverse mammary epithelial cells induced claudin-low-like TNBC with Met, Birc2/3-Mmp13-Yap1, and Pvt1-Myc amplifications. 27571409 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Patient survival according to ESR2 expression levels and TP53 mutation status was analyzed in the basal-like TNBC subgroup in the Molecular Taxonomy of Breast Cancer International Consortium (n = 308) and Roswell Park Comprehensive Cancer Center (n = 46) patient cohorts by univariate Cox regression and log-rank test.All statistical tests are two-sided. 30990221 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE The expression of p53 was higher in luminal B, HER2-enriched, and triple-negative breast cancers, and this was positively correlated with the expression of EGFR in TNBC but not in the other subtypes. p53 and EGFR expression was positively correlated in TNBC, which enables us to explore the molecular biological characteristics of TNBC, so as to provide new ideas for the treatment of TNBC. 25966200 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE These results demonstrate the potential of the pH-responsive nanoparticle and the precise POLR2A targeted therapy in TNBC harbouring the common TP53 genomic alteration. 30804480 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Depletion of NFIB in TP53-mutated TNBC cell lines promotes cell death, cell cycle arrest, and enhances sensitivity to docetaxel, a first-line chemotherapeutic drug in breast cancer treatment. 30350349 2019