| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.060 | PosttranslationalModification | disease | BEFREE | Although there was significant difference in disease-free survival (DFS) and overall survival (OS) between TNBC and ER+PR+Her2- group, further analysis of co-methylation of p16 and RASSF1A (p16+RASSF1A+) showed that DFS was significantly shorter in the patients with both genes co-methylated in TNBC than in ER+PR+Her-2- group (8/20; 40% vs. 2/10; 20%, p=0.03272). | 30003738 | 2019 | ||||
|
0.060 | Biomarker | disease | BEFREE | A further paradox revolves around the observation that, while cell senescence should inhibit proliferation, the senescence marker p16INK4a correlates with poor treatment outcome in patients with a very aggressive triple-negative breast carcinoma (TNBC). | 26860864 | 2016 | ||||
|
0.060 | Biomarker | disease | BEFREE | Methylation of glutathione S-transferase P1 (GSTP1), T-cadherin (CDH13), Paired box protein 5 (PAX5), death associated protein kinase (DAPK), twist-related protein (TWIST), DNA-binding protein inhibitor (ID4), High In Normal-1 (HIN-1), cyclin-dependent kinase inhibitor 2A (p16), cyclin D2 and retinoic acid receptor-β (RARβ1) genes was analyzed by methylation specific polymerase chain reaction (MSP) in 200 archival formalin- fixed paraffin embedded BC tissues divided into 3 groups; benign breast tissues (20), TNBC (80) and non-TNBC (100). | 25684485 | 2015 | ||||
|
0.060 | AlteredExpression | disease | BEFREE | Human triple-negative breast cancer (TNBC) tumor samples with coinactivation of p53 and ARF exhibit high expression of both STAT1 and ISG15, and TNBC cell lines are sensitive to STAT1 depletion. | 24726362 | 2014 | ||||
|
0.060 | Biomarker | disease | BEFREE | The genes c-Myc, p21, and p16 were correlated with the prognosis of TNBC and therefore may have potential clinical application values in the prognostic prediction of TNBC. | 24096545 | 2014 | ||||
|
0.060 | Biomarker | disease | BEFREE | In this study, we investigated p16 expression in 60 high-grade invasive TNBC cases and its relationship with Ki-67 in different groups of TNBCs and correlated p16 with Ki-67 in p53-positive and p53-negative subgroups. | 24560018 | 2014 |