Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 AlteredExpression disease BEFREE Prediction of postoperative survival of triple-negative breast cancer based on nomogram model combined with expression of HIF-1α and c-myc. 31577739 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 AlteredExpression disease BEFREE To elucidate the role of the mammalian target of rapamycin (mTOR) signaling pathway in TNBC, the expression of molecules involved in mTOR signaling including mTOR, phosphorylated (p)-mTOR, p-4EBP1, GLUT1, GLUT3, HIF-1α, and Ki67 was investigated by immunohistochemistry in 35 TNBC and 81 non-TNBC cases. 31707383 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 AlteredExpression disease BEFREE The protein level of HIF-1α remains largely unchanged in cultured TNBC cells and xenografts, partially due to its upregulated transcription by vitamin C, suggesting that HIF-1α unlikely mediates the action of vitamin C on metastasis. 31817810 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE Cardamonin inhibited growth of the triple negative breast cancer cell line MDA-MB-231 in vitro and in vivo by suppressing HIF-1α mediated cell metabolism. 31455352 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE Previous studies have revealed that long intergenic non-coding RNA for kinase activation (LINK-A), a long non-coding RNA (lncRNA) promotes disease progression in triple-negative breast cancer by activating hypoxia-inducible factor 1α (HIF1α). 31258644 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE Among them, compound 57 showed potent HIF-1α inhibition and cytotoxicity in triple-negative breast cancer lines in a dose-dependent manner. 30827868 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts. 31529195 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE These surprising results delineate a mechanism by which a transcription factor switches cells from ERK to p38 signaling in response to chemotherapy and suggest that therapeutic targeting of HIF1 or the p38 pathway in combination with chemotherapy will block BCSC enrichment and improve outcome in TNBC.<b>Significance:</b> These findings provide a molecular mechanism that may account for the increased relapse rate of women with TNBC who are treated with cytotoxic chemotherapy and suggest that combining chemotherapy with an inhibitor of HIF1 or p38 activity may increase patient survival.<i></i>. 29880481 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE Psammaplin-based histone deacetylase (HDAC) inhibitors were found to differentially inhibit HDAC activity, induce activation of hypoxia-inducible factor-1 (HIF-1), and disrupt organotropic metastatic TNBC subclone growth. 30423844 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 AlteredExpression disease BEFREE Bioinformatic analysis further indicated a mechanism by which HIF-1α can regulate ST3GAL6 expression and the relationship within the intrinsic characteristics of TNBC tumors. 29894296 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE For improving the therapeutic efficacy of TNBC, we developed a new kind of multifunctional cationic porphyrin-grafted lipid (CPGL) microbubble loaded with HIF 1α siRNA (siHIF@CpMB). 30346453 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE These data suggest that (1) MYC and MCL1 confer resistance to chemotherapy by expanding CSCs via mtOXPHOS and (2) targeting mitochondrial respiration and HIF-1α may reverse chemotherapy resistance in TNBC. 28978427 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE In summary, multiple cycles of hypoxia and reoxygenation have a more pronounced effect on the promotion of TNBC invasiveness than CH; HIF-1α activation and downstream vimentin upregulation may account for this phenotypic change. 29250173 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 AlteredExpression disease BEFREE Nonetheless, how HIF-1α expression is regulated and how HIF-1α induces aggressive phenotype are not completely understood in TNBC. 27137755 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 AlteredExpression disease BEFREE PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes. 28239645 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE Levels of HIF-1α and stem cells in the tumor were quantitated by Western blotting and flow cytometry.<b>Results:</b> The magnitude (<i>P</i> < 0.001) and incidence (<i>P</i> < 0.001) of HIF-1α-specific IgG were elevated in TNBC patients compared with controls. 28039264 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 AlteredExpression disease BEFREE The suppression of IL-6 by G-1 can further inhibit HIF-1α and STAT3 signals in TNBC cells by inhibition their expression, phosphorylation and/or nuclear localization. 27836733 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE Our study suggests a tumor-suppressive function of PRC2, which is restricted by HIF1-α, and an oncogenic function of Ezh2, which cooperates with FoxM1 to promote invasion in triple-negative breast cancer. 27303043 2016
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE Immunohistochemical staining for HIF1α and CAIX was performed to determine the correlation with clinicopathologic variables and survival outcome on tissue microarrays from 270 early-stage TNBC patients. 27184798 2016
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 AlteredExpression disease BEFREE Treatment of TNBC cell lines with dutasteride was associated with a dose-dependent decrease in cell viability, altered protein expression of VEGF and HIF-1α and increased chemosensitivity. 25356777 2015
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 AlteredExpression disease BEFREE Expression of HIF-1α and Markers of Angiogenesis Are Not Significantly Different in Triple Negative Breast Cancer Compared to Other Breast Cancer Molecular Subtypes: Implications for Future Therapy. 26046764 2015
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE In conclusion, the recombinant lentivirus containing HIF-1α siRNA provides a new avenue for developing novel therapy for triple negative breast cancer. 25920936 2015
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE These results suggest that, in combination with chemotherapy, targeting BCSCs by inhibiting HIF-1-regulated glutathione synthesis may improve outcome in TNBC. 26229077 2015
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 AlteredExpression disease BEFREE Analysis of independent cohorts of patients with TNBC revealed a specific XBP1 gene expression signature that was highly correlated with HIF1α and hypoxia-driven signatures and that strongly associated with poor prognosis. 24670641 2014
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker disease BEFREE Primary tumors of ganetespib-treated mice had significantly reduced levels of HIF-1α (but not HIF-2α) protein and of HIF-1 target gene mRNAs encoding proteins that play key roles in angiogenesis, metabolism, invasion, and metastasis, thereby providing a molecular basis for observed effects of the drug on the growth and metastasis of triple-negative breast cancer. 24248265 2014