Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression disease BEFREE Consistent with this data, PTEN-null TNBC tumors expressed higher levels of STING, and PTEN-null TNBC cell lines were hyperresponsive to STING agonists. 31662325 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression disease BEFREE The AKT inhibitor capivasertib has shown preclinical activity in TNBC models, and drug sensitivity has been associated with activation of PI3K or AKT and/or deletions of PTEN. 31841354 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression disease BEFREE Downregulation of long noncoding RNA HCP5 contributes to cisplatin resistance in human triple-negative breast cancer via regulation of PTEN expression. 31028999 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker disease BEFREE Our data revealed that treatment of the TNBC VM phenotype cells with entinostat epigenetically led to the re‑expression of the anti‑angiogenic genes, serpin family F member 1 (SERPINF1) and thrombospondin 2 (THBS2), and to that of the tumor suppressor genes, phosphatase and tensin homolog (PTEN) and p21, and reduced VM structures. 31059004 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker disease BEFREE Here, show that these PTEN-low/miRNA-low lesions cluster with BL1 TNBC. 31836816 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression disease BEFREE Three TNBC-PDX models (WHIM6, WHIM12 and WHIM21), all with loss of PTEN expression, were tested for their response to BKM120 and eribulin, alone or in combination <i>in vivo</i>. 31217901 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression disease BEFREE A subgroup of TNBC patients with PTEN-low and reduced expression of four or five of these miRs exhibited the worst clinical outcome relative to other TNBCs (hazard ratio (HR) = 3.91; P < 0.0001), and this was validated on an independent cohort (HR = 4.42; P = 0.0003). 30704524 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression disease BEFREE The dCas9-VPR system increased PTEN expression in melanoma and TNBC cell lines, without transcriptional regulation at predicted off-target sgRNA binding sites. 30654190 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker disease BEFREE Consequently, this study firstly reveals that up-regulated LINC00152 mediates PTEN protein stability attenuation in TNBC. 30594392 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker disease BEFREE IHC in metastatic tumors, showed that the percentage of tumors positive of EGFR were higher, while PTEN and TLE3 were lower in QNBC compared to TNBC. 30594038 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker disease BEFREE ORR was 0% and 6 m PFS was 11% (1/9), observed in a patient with triple-negative breast cancer and PTEN loss. 31277699 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation disease BEFREE In this study, we used the Ion Personal Genome Machine (PGM) and Ion Torrent Ampliseq Cancer panel to sequence hotspot regions from PIK3CA, AKT and PTEN genes to identify genetic mutations in 39 samples of TNBC subtype from Moroccan patients and to correlate the results with clinical-pathologic data. 30227836 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression disease BEFREE These data suggest that combination treatments targeting the intersection of the Notch, AKT and NF-κB pathways have potential therapeutic applications against CSCs in TNBC cases with Notch1 and wild-type PTEN expression. 30564555 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker disease BEFREE In triple-negative breast cancer (TNBC), RB1 and PTEN are frequently inactivated together with TP53. 29617654 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation disease BEFREE These results suggest that patients with BRCA1-associated TNBC without genetic alterations in the PTEN and KRAS genes may have improved therapeutic responses to anti-EGFR mAbs combined with DNA-damaging agents. 27864890 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression disease BEFREE The density of CD3<sup>+</sup> TILs, CD8<sup>+</sup> TILs, and CD163<sup>+</sup> macrophages and non-expression of PTEN was significantly higher in cases of triple negative breast cancer. 27801993 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation disease BEFREE Three PDXs were selected for their lack of PTEN expression by immunohistochemistry: a triple-negative breast cancer (TNBC), a <i>KRAS</i> G12R low-grade serous ovarian cancer (LGSOC), and <i>KRAS</i> G12C and <i>TP53</i> R181P lung adenocarcinoma (LADC). 29156674 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression disease BEFREE Inhibition of miR-21 or overexpression of PTEN protein could be promising strategies for the treatment of patients with TNBC. 28386324 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation disease BEFREE Triple-negative breast cancer (TNBC), an aggressive disease comprising several subtypes including basal-like and claudin-low, involves frequent deletions or point mutations in TP53, as well as loss of PTEN. 26781438 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker disease BEFREE Application of DGCA to the TCGA RNA-seq data in breast cancer not only identifies key changes in the regulatory relationships between TP53 and PTEN and their target genes in the presence of inactivating mutations, but also reveals an immune-related differential correlation module that is specific to triple negative breast cancer (TNBC). 27846853 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker disease BEFREE Our findings suggest that expression of functional PTEN may serve as a biomarker for selecting TNBC patients that would favorably respond to a combination of olaparib with SAHA. 25888415 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker disease BEFREE We used cell line models of EGFR-positive/PTEN null TNBC to elucidate the signaling networks that drive the malignant features of these cells and cause resistance to EGFR inhibitors. 25454348 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression disease BEFREE Loss of PTEN expression is associated with aggressive behavior and poor prognosis in Middle Eastern triple-negative breast cancer. 25981902 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression disease BEFREE High levels of the oncogenic miRNA (oncomiR) guide strand called miR-17-5p is overexpressed in triple negative breast cancer (TNBC) and can inhibit ribosomal translation of tumor suppressor gene mRNAs, such as programmed cell death 4 (PDCD4) or phosphatase and tensin homolog (PTEN). 26629823 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation disease BEFREE A recent molecular and mutational analysis of breast cancers revealed that inactivation of tumor suppressors, p53 and PTEN, are strongly associated with triple negative breast cancer. 24531711 2015