| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | The death receptor TRAIL-R2 was upregulated in response to CIB1 depletion, which sensitized TNBC cells to the ligand TRAIL, resulting in a synergistic increase in cell death. | 30740034 | 2019 | ||||
|
0.090 | Biomarker | disease | BEFREE | These results suggest that CaM could be a key regulator to mediate DR5-mediated apoptotic signaling, and suggests a potential strategy for using CaM antagonists to overcome drug resistance of TRAIL-based therapy for TRA-8 resistant TNBC. | 29663486 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | Metformin sensitizes triple-negative breast cancer to proapoptotic TRAIL receptor agonists by suppressing XIAP expression. | 28324269 | 2017 | ||||
|
0.090 | Biomarker | disease | BEFREE | An induction of apoptosis and DR5 expression was noticed in xenograft mice and in TNBC patient-derived metastatic cells after TRAIL+ET treatment. | 28702823 | 2017 | ||||
|
0.090 | Biomarker | disease | BEFREE | These results suggest that the treatment of hMSCs with a sub-toxic dose of doxorubicin can overcome TRAIL resistance and be a potential novel therapy for TNBC metastasis treatment. | 26227206 | 2015 | ||||
|
0.090 | Biomarker | disease | BEFREE | To identify the mechanism by which residual cancer cells survive chemotherapy, we initially conducted gene expression profiling using the CRL2335 TNBC cell line derived from a squamous breast carcinoma before and after treatment with cisplatin plus TRAIL. | 23445611 | 2013 | ||||
|
0.090 | Biomarker | disease | BEFREE | Resulting immune serum or purified immune IgG induced apoptosis in triple-negative breast cancer (TNBC) cells, which were also TRAIL sensitive. | 22419388 | 2012 | ||||
|
0.090 | Biomarker | disease | BEFREE | Taken together, the data suggest that the combination of WEE1 inhibitor and TRAIL could provide a novel combination for the treatment of basal/triple-negative breast cancer. | 22112940 | 2012 | ||||
|
0.090 | Biomarker | disease | BEFREE | Specific inhibition of EGFR and/or p63 protein in TNBC cells by small interfering RNA (siRNA) does not increase TRAIL-induced apoptosis. | 21252285 | 2011 |