Source: ALL
Associated Disease N. genes N. variants N. of shared genes JI g p-value g N. of shared variants JI v p-value v
CUI: C0231687
Disease: Spastic gait
Spastic gait 		62 9 15 0.18 2 0.15
CUI: C0238651
Disease: Ankle clonus
Ankle clonus 		32 5 9 0.15 1 1.0E-01
CUI: C0037771
Disease: Paraparesis, Spastic
Paraparesis, Spastic 		75 0 14 0.14 0 0
CUI: C0751602
Disease: Hereditary Autosomal Dominant Spastic Paraplegia
Hereditary Autosomal Dominant Spastic Paraplegia 		27 0 8 0.14 0 0
CUI: C1843663
Disease: Urinary bladder sphincter dysfunction
Urinary bladder sphincter dysfunction 		28 0 8 0.14 0 0
CUI: C1849134
Disease: Impaired vibration sensation in the lower limbs
Impaired vibration sensation in the lower limbs 		39 4 9 0.13 1 0.11
CUI: C1836296
Disease: Muscle Weakness Lower Limb
Muscle Weakness Lower Limb 		74 0 13 0.13 0 0
CUI: C0037772
Disease: Spastic Paraplegia
Spastic Paraplegia 		144 93 21 0.13 1 1.0E-02
CUI: C0037773
Disease: Spastic Paraplegia, Hereditary
Spastic Paraplegia, Hereditary 		123 0 18 0.13 0 0
CUI: C1271100
Disease: Lower limb spasticity
Lower limb spasticity 		43 0 9 0.12 0 0
CUI: C0034935
Disease: Babinski Reflex
Babinski Reflex 		218 11 27 0.12 1 6.2E-02
CUI: C1836451
Disease: Distal lower limb amyotrophy
Distal lower limb amyotrophy 		29 8 7 0.12 1 7.7E-02
CUI: C1845245
Disease: Lower limb hypertonia
Lower limb hypertonia 		21 0 6 0.11 0 0
CUI: C2673700
Disease: Brisk reflexes
Brisk reflexes 		31 7 7 0.11 1 8.3E-02
CUI: C0542223
Disease: Loss of speech
Loss of speech 		37 0 7 0.10 0 0
CUI: C1858712
Disease: Spastic paraplegia 10, autosomal dominant
Spastic paraplegia 10, autosomal dominant 		16 0 5 0.10 0 0
CUI: C0085606
Disease: Urgency of micturition
Urgency of micturition 		40 1 7 9.9E-02 1 0.17
CUI: C1859520
Disease: Progressive spasticity
Progressive spasticity 		19 5 5 9.6E-02 1 1.0E-01
CUI: C1846566
Disease: Degeneration of the lateral corticospinal tracts
Degeneration of the lateral corticospinal tracts 		21 0 5 9.3E-02 0 0
CUI: C4553976
Disease: Urinary Urgency, CTCAE 5
Urinary Urgency, CTCAE 5 		34 0 6 9.1E-02 0 0
CUI: C1855483
Disease: Progressive spastic paraplegia
Progressive spastic paraplegia 		59 1 8 9.0E-02 1 0.17
CUI: C1263857
Disease: Peripheral axonal neuropathy
Peripheral axonal neuropathy 		94 0 10 8.2E-02 0 0
CUI: C0393556
Disease: Complicated hereditary spastic paraplegia
Complicated hereditary spastic paraplegia 		16 0 4 8.0E-02 0 0
CUI: C1843175
Disease: Hyperreflexia in upper limbs
Hyperreflexia in upper limbs 		16 0 4 8.0E-02 0 0
CUI: C0454596
Disease: Dysarthria, Spastic
Dysarthria, Spastic 		30 0 5 7.9E-02 0 0