Disease: Amyotrophic Lateral Sclerosis
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
RMDN3 Q96TC7 regulator of microtubule dynamics 3 5.2E-05 0.534 0.769
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962
PAWR Q96IZ0 pro-apoptotic WT1 regulator 9.0E-02 0.542 0.846
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885
OPTN Q96CV9 optineurin 5.9E-18 0.548 0.808
APH1A Q96BI3 aph-1 homolog A, gamma-secretase subunit Enzyme modulator 0.79 0.656 0.538
HDAC2 Q92769 histone deacetylase 2 Epigenetic regulator 1.00 0.476 0.846
ESR2 Q92731 estrogen receptor 2 Nuclear receptor 4.5E-08 0.400 0.923
NRGN Q92686 neurogranin 0.48 0.608 0.615
ASCC1 Q8N9N2 activating signal cointegrator 1 complex subunit 1 2.6E-14 0.495 0.846
TICAM1 Q8IUC6 toll like receptor adaptor molecule 1 0.593 0.846
TRIM69 Q86WT6 tripartite motif containing 69 2.6E-09 0.612 0.731
CD163 Q86VB7 CD163 molecule Enzyme 8.3E-04 0.427 0.846
PRRT2 Q7Z6L0 proline rich transmembrane protein 2 0.58 0.448 0.808
TSHZ1 Q6ZSZ6 teashirt zinc finger homeobox 1 Transcription factor 1.00 0.569 0.731
LRRK2 Q5S007 leucine rich repeat kinase 2 Kinase 2.6E-30 0.510 0.808
HSP90B2P Q58FF3 heat shock protein 90 beta family member 2, pseudogene Chaperone 0.558 0.846
SMUG1 Q53HV7 single-strand-selective monofunctional uracil-DNA glycosylase 1 4.5E-04 0.322 0.923
HFE Q30201 homeostatic iron regulator 2.6E-08 0.436 0.846
DECR1 Q16698 2,4-dienoyl-CoA reductase 1 Enzyme 4.5E-14 0.426 0.885
SMN1 Q16637 survival of motor neuron 1, telomeric Epigenetic regulator 1.6E-02 0.454 0.769
SMN2 Q16637 survival of motor neuron 2, centromeric 0.10 0.459 0.769
OCLN Q16625 occludin 8.6E-07 0.507 0.846
NTRK2 Q16620 neurotrophic receptor tyrosine kinase 2 Kinase 1.00 0.479 0.808
CAMK4 Q16566 calcium/calmodulin dependent protein kinase IV Kinase 0.51 0.621 0.654