Disease: Mental deficiency
Source: CURATED ×
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
VIP P01282 vasoactive intestinal peptide Signaling 4.2E-04 0.437 0.846
SYNGAP1 Q96PV0 synaptic Ras GTPase activating protein 1 Enzyme modulator 1.00 0.584 0.577
SHANK3 Q9BYB0 SH3 and multiple ankyrin repeat domains 3 1.00 0.550 0.731
SHANK2 Q9UPX8 SH3 and multiple ankyrin repeat domains 2 8.4E-07 0.663 0.385
RAB39B Q96DA2 RAB39B, member RAS oncogene family 0.83 0.619 0.615
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
PTCHD1 Q96NR3 patched domain containing 1 Receptor 0.98 0.678 0.385
PAX6 P26367 paired box 6 1.00 0.450 0.769
NTF4 P34130 neurotrophin 4 Signaling 1.2E-02 0.644 0.692
NSD1 Q96L73 nuclear receptor binding SET domain protein 1 Epigenetic regulator 1.00 0.505 0.769
NRXN1 P58400 Q9ULB1 neurexin 1 1.00 0.581 0.692
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885
MEF2C Q06413 myocyte enhancer factor 2C Transcription factor 1.7E-02 0.517 0.769
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846
MCC P23508 MCC regulator of WNT signaling pathway 4.7E-16 0.568 0.731
KDM5C P41229 lysine demethylase 5C 1.00 0.581 0.538
GRIN2B Q13224 glutamate ionotropic receptor NMDA type subunit 2B Ion channel 1.00 0.510 0.692
FMR1 Q06787 FMRP translational regulator 1 Nucleic acid binding 0.65 0.473 0.769
DISC1 Q9NRI5 DISC1 scaffold protein 1.7E-06 0.548 0.769
CHD8 Q9HCK8 chromodomain helicase DNA binding protein 8 1.00 0.656 0.577
CALCA P01258 P06881 calcitonin related polypeptide alpha Signaling 1.6E-02 0.416 0.923
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962
AHI1 Q8N157 Abelson helper integration site 1 1.1E-25 0.513 0.846