Source: CLINVAR ×
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923
TWIST1 Q15672 twist family bHLH transcription factor 1 Transcription factor 0.34 0.397 0.846
DMD P11532 dystrophin 1.00 0.423 0.923
SMARCB1 Q12824 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Nucleic acid binding 1.00 0.434 0.846
RAD51 Q06609 RAD51 recombinase 2.7E-02 0.447 0.846
SOS1 Q07889 SOS Ras/Rac guanine nucleotide exchange factor 1 Enzyme modulator 1.00 0.485 0.808
RYR1 P21817 ryanodine receptor 1 Ion channel 1.6E-29 0.489 0.808
SYNE1 Q8NF91 spectrin repeat containing nuclear envelope protein 1 3.2E-52 0.511 0.846
RIT1 Q92963 Ras like without CAAX 1 Enzyme modulator 0.13 0.527 0.808
KIF7 Q2M1P5 kinesin family member 7 2.3E-22 0.528 0.731
RAD21 O60216 RAD21 cohesin complex component 1.00 0.528 0.846
HUWE1 Q7Z6Z7 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 Enzyme 1.00 0.534 0.769
PUF60 Q9UHX1 poly(U) binding splicing factor 60 1.00 0.536 0.769
HNRNPK P61978 heterogeneous nuclear ribonucleoprotein K Enzyme 1.00 0.539 0.846
CNTNAP1 P78357 contactin associated protein 1 3.4E-05 0.554 0.577
ANKRD11 Q6UB99 ankyrin repeat domain 11 1.00 0.556 0.808
KLHL7 Q8IXQ5 kelch like family member 7 4.6E-05 0.581 0.731
SYNGAP1 Q96PV0 synaptic Ras GTPase activating protein 1 Enzyme modulator 1.00 0.584 0.577
MPV17 P39210 mitochondrial inner membrane protein MPV17 Receptor 9.7E-11 0.595 0.577
PIGQ Q9BRB3 phosphatidylinositol glycan anchor biosynthesis class Q Enzyme 1.4E-06 0.610 0.577
ASXL2 Q76L83 ASXL transcriptional regulator 2 1.00 0.617 0.692
MED13L Q71F56 mediator complex subunit 13L 1.00 0.617 0.538
TRAF7 Q6Q0C0 TNF receptor associated factor 7 2.2E-02 0.623 0.423