Gene | Uniprot | Gene Full Name | Protein Class | pLI | DSI v | DPI v |
---|---|---|---|---|---|---|
PTEN | P60484 | phosphatase and tensin homolog | Enzyme | 0.26 | 0.305 | 0.923 |
PIK3CA | P42336 | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Kinase | 1.00 | 0.292 | 0.923 |
TP53 | P04637 | tumor protein p53 | Transcription factor | 0.53 | 0.236 | 0.962 |
BRCA2 | P51587 | BRCA2 DNA repair associated | Nucleic acid binding | 2.4E-25 | 0.379 | 0.846 |
KRAS | P01116 | KRAS proto-oncogene, GTPase | Enzyme modulator | 7.9E-04 | 0.320 | 0.923 |
PALB2 | Q86YC2 | partner and localizer of BRCA2 | 3.0E-19 | 0.485 | 0.769 | |
CHEK2 | O96017 | checkpoint kinase 2 | Kinase | 1.2E-24 | 0.460 | 0.808 |
ATM | Q13315 | ATM serine/threonine kinase | Kinase | 5.6E-47 | 0.374 | 0.885 |
RET | P07949 | ret proto-oncogene | Kinase | 1.00 | 0.392 | 0.885 |
APC | P25054 | APC regulator of WNT signaling pathway | 1.00 | 0.373 | 0.962 | |
PMS2 | P54278 | PMS1 homolog 2, mismatch repair system component | Nucleic acid binding | 4.5E-27 | 0.484 | 0.808 |
C11orf65 | Q8NCR3 | chromosome 11 open reading frame 65 | 2.0E-14 | 0.670 | 0.462 | |
BRCA1 | P38398 | BRCA1 DNA repair associated | Enzyme | 9.2E-29 | 0.367 | 0.923 |
CDKN2A | P42771 Q8N726 | cyclin dependent kinase inhibitor 2A | 0.39 | 0.300 | 0.885 | |
MSH2 | P43246 | mutS homolog 2 | Nucleic acid binding | 0.90 | 0.406 | 0.808 |
MSH6 | P52701 | mutS homolog 6 | Nucleic acid binding | 3.7E-05 | 0.462 | 0.731 |
FBXO11 | Q86XK2 | F-box protein 11 | Enzyme | 1.00 | 0.604 | 0.692 |
MUTYH | Q9UIF7 | mutY DNA glycosylase | Enzyme | 1.3E-18 | 0.521 | 0.769 |
MLH1 | P40692 | mutL homolog 1 | Nucleic acid binding | 3.4E-05 | 0.399 | 0.808 |
BRIP1 | Q9BX63 | BRCA1 interacting protein C-terminal helicase 1 | Enzyme | 6.2E-17 | 0.507 | 0.731 |
NBN | O60934 | nibrin | Nucleic acid binding | 2.2E-16 | 0.467 | 0.808 |
CDH1 | P12830 | cadherin 1 | 0.15 | 0.401 | 0.808 | |
CYTB | P00156 | cytochrome b | 0.529 | 0.808 | ||
BARD1 | Q99728 | BRCA1 associated RING domain 1 | 1.4E-24 | 0.597 | 0.538 | |
TRNE | tRNA | 0.647 | 0.692 |