Disease: Hereditary Breast and Ovarian Cancer Syndrome
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
APRT P07741 adenine phosphoribosyltransferase 5.5E-13 0.423 0.846
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923
CDK2 P24941 cyclin dependent kinase 2 Kinase 0.61 0.456 0.692
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
EPHA3 P29320 EPH receptor A3 Kinase 1.2E-05 0.497 0.692
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
FANCC Q00597 FA complementation group C 2.8E-13 0.507 0.808
FAP Q12884 fibroblast activation protein alpha Enzyme 1.9E-28 0.496 0.808
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885
IGFBP4 P22692 insulin like growth factor binding protein 4 Enzyme modulator 2.3E-02 0.572 0.731
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
MFAP1 P55081 microfibril associated protein 1 Extracellular structure 0.80 0.431 0.846
MIR146A microRNA 146a 0.398 0.885
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
MRE11 P49959 MRE11 homolog, double strand break repair nuclease 1.3E-12 0.527 0.808
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
MSH3 P20585 mutS homolog 3 Nucleic acid binding 7.4E-31 0.474 0.769
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731
NBN O60934 nibrin Nucleic acid binding 2.2E-16 0.467 0.808
NOTCH3 Q9UM47 notch receptor 3 0.41 0.435 0.808
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808
PRSS1 P07477 serine protease 1 Enzyme 4.1E-11 0.563 0.692