| Gene | Uniprot | Gene Full Name | Protein Class | pLI | DSI v | DPI v |
|---|---|---|---|---|---|---|
| APC | P25054 | APC regulator of WNT signaling pathway | 1.00 | 0.373 | 0.962 | |
| BRCA2 | P51587 | BRCA2 DNA repair associated | Nucleic acid binding | 2.4E-25 | 0.379 | 0.846 |
| MLH1 | P40692 | mutL homolog 1 | Nucleic acid binding | 3.4E-05 | 0.399 | 0.808 |
| MSH2 | P43246 | mutS homolog 2 | Nucleic acid binding | 0.90 | 0.406 | 0.808 |
| MSH6 | P52701 | mutS homolog 6 | Nucleic acid binding | 3.7E-05 | 0.462 | 0.731 |
| NRAS | P01111 | NRAS proto-oncogene, GTPase | Enzyme modulator | 0.49 | 0.390 | 0.808 |
| PALB2 | Q86YC2 | partner and localizer of BRCA2 | 3.0E-19 | 0.485 | 0.769 | |
| PIK3CA | P42336 | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Kinase | 1.00 | 0.292 | 0.923 |
| PMS2 | P54278 | PMS1 homolog 2, mismatch repair system component | Nucleic acid binding | 4.5E-27 | 0.484 | 0.808 |
| PTCH1 | Q13635 | patched 1 | 1.00 | 0.398 | 0.885 | |
| PTCH2 | Q9Y6C5 | patched 2 | 3.4E-16 | 0.563 | 0.692 | |
| SMO | Q99835 | smoothened, frizzled class receptor | G-protein coupled receptor | 4.3E-07 | 0.489 | 0.731 |
| SUFU | Q9UMX1 | SUFU negative regulator of hedgehog signaling | 1.00 | 0.493 | 0.769 | |
| TP53 | P04637 | tumor protein p53 | Transcription factor | 0.53 | 0.236 | 0.962 |