Disease: Familial Alzheimer Disease (FAD)
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923
C9orf72 Q96LT7 C9orf72-SMCR8 complex subunit 1.1E-06 0.496 0.769
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923
CDK5R1 Q15078 cyclin dependent kinase 5 regulatory subunit 1 Enzyme modulator 0.91 0.529 0.808
CHRNA7 P36544 Q494W8 cholinergic receptor nicotinic alpha 7 subunit Ion channel 4.2E-04 0.532 0.654
CHRNB2 P17787 cholinergic receptor nicotinic beta 2 subunit Ion channel 7.3E-04 0.617 0.308
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
CTSB P07858 cathepsin B Enzyme 5.9E-11 0.457 0.846
EIF2S1 P05198 eukaryotic translation initiation factor 2 subunit alpha Nucleic acid binding 0.97 0.587 0.692
ERBB4 Q15303 erb-b2 receptor tyrosine kinase 4 Kinase 1.00 0.455 0.846
F2 P00734 coagulation factor II, thrombin Enzyme 1.1E-03 0.415 0.885
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923
IDUA P35475 alpha-L-iduronidase Enzyme 3.8E-13 0.499 0.846
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885
LEP P41159 leptin 0.46 0.349 0.846
LRP8 Q14114 LDL receptor related protein 8 1.00 0.644 0.346
MAPK3 P27361 mitogen-activated protein kinase 3 Kinase 3.7E-02 0.379 0.885
NGF P01138 nerve growth factor Signaling 0.82 0.391 0.885
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885
PRNP F7VJQ1 P04156 prion protein 6.3E-04 0.445 0.923