Disease: Juvenile Myelomonocytic Leukemia
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846
CBL P22681 Cbl proto-oncogene Enzyme 6.1E-04 0.527 0.769
CBLL2 Q8N7E2 Cbl proto-oncogene like 2 Enzyme 0.476 0.808
EPHB2 P29323 EPH receptor B2 Kinase 1.00 0.374 0.846
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
MAP2K7 O14733 mitogen-activated protein kinase kinase 7 Kinase 1.00 0.419 0.808
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923
MIR223 microRNA 223 0.433 0.808
MUL1 Q969V5 mitochondrial E3 ubiquitin protein ligase 1 1.9E-06 0.473 0.808
MVD P53602 mevalonate diphosphate decarboxylase 2.7E-17 0.568 0.769
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808
PDGFRB P09619 platelet derived growth factor receptor beta Kinase 0.90 0.416 0.846
PRKN O60260 parkin RBR E3 ubiquitin protein ligase Enzyme 6.9E-07 0.431 0.846
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923
RAF1 P04049 Raf-1 proto-oncogene, serine/threonine kinase Kinase 0.85 0.418 0.885
REG1A P05451 regenerating family member 1 alpha 1.3E-05 0.467 0.846
RIT1 Q92963 Ras like without CAAX 1 Enzyme modulator 0.13 0.527 0.808
RNASE3 P12724 ribonuclease A family member 3 0.490 0.808
RRAS P10301 RAS related Enzyme modulator 4.7E-03 0.543 0.808
RRAS2 P62070 RAS related 2 Enzyme modulator 0.97 0.656 0.500
SGSM3 Q96HU1 small G protein signaling modulator 3 Enzyme 3.4E-15 0.469 0.808