Disease: Hypercholesterolemia, Familial
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923
ALOX5 P09917 arachidonate 5-lipoxygenase Enzyme 1.2E-06 0.447 0.885
APOA1 P02647 apolipoprotein A1 5.5E-04 0.429 0.885
CD28 P10747 CD28 molecule 0.36 0.436 0.885
CH25H O95992 cholesterol 25-hydroxylase Enzyme 0.23 0.663 0.577
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
HMGA2 P52926 high mobility group AT-hook 2 Nucleic acid binding 0.87 0.429 0.808
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923
IL6 P05231 interleukin 6 0.32 0.248 0.962
ITGB2 P05107 integrin subunit beta 2 Receptor 5.1E-15 0.444 0.923
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885
NR3C1 P04150 nuclear receptor subfamily 3 group C member 1 Nuclear receptor 0.97 0.393 0.885
REN P00797 renin Enzyme 2.4E-07 0.370 0.923
RUNX1 Q01196 RUNX family transcription factor 1 Transcription factor 0.65 0.425 0.808
S100A12 P80511 S100 calcium binding protein A12 Calcium-binding protein 0.48 0.488 0.846
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885
SP1 P08047 Sp1 transcription factor Nucleic acid binding 1.00 0.493 0.769
STAT1 P42224 signal transducer and activator of transcription 1 Nucleic acid binding 1.00 0.399 0.885
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962