Disease: Premature aging syndrome
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885
BLM P54132 BLM RecQ like helicase 1.5E-15 0.535 0.808
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
DKC1 O60832 dyskerin pseudouridine synthase 1 Nucleic acid binding 1.00 0.547 0.769
EFEMP1 Q12805 EGF containing fibulin extracellular matrix protein 1 Extracellular structure 1.00 0.540 0.769
ENOSF1 Q7L5Y1 enolase superfamily member 1 Enzyme 9.0E-19 0.617 0.654
ERCC4 Q92889 ERCC excision repair 4, endonuclease catalytic subunit Enzyme 1.4E-12 0.468 0.846
H3P10 H3 histone pseudogene 10 0.350 0.846
IGFBP3 P17936 insulin like growth factor binding protein 3 Enzyme modulator 0.91 0.439 0.808
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962
LMNA P02545 lamin A/C 1.00 0.384 0.885
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846
RAD51 Q06609 RAD51 recombinase 2.7E-02 0.447 0.846
RECQL4 O94761 RecQ like helicase 4 Enzyme 3.3E-35 0.496 0.808
RECQL5 O94762 RecQ like helicase 5 Enzyme 3.2E-18 0.682 0.500
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885
SIRT6 Q8N6T7 sirtuin 6 Epigenetic regulator 3.9E-02 0.496 0.846
TOP3A Q13472 DNA topoisomerase III alpha Enzyme 5.1E-11 0.656 0.615
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
WRN Q14191 WRN RecQ like helicase Enzyme 2.6E-34 0.524 0.808
WRNIP1 Q96S55 WRN helicase interacting protein 1 Enzyme 2.5E-02 0.931 0.115