Disease: Breast Cancer, Familial
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885
ATR Q13535 ATR serine/threonine kinase Kinase 3.5E-09 0.456 0.923
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
CHEK1 O14757 checkpoint kinase 1 Kinase 3.1E-08 0.492 0.808
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
ERCC4 Q92889 ERCC excision repair 4, endonuclease catalytic subunit Enzyme 1.4E-12 0.468 0.846
EXO1 Q9UQ84 exonuclease 1 Enzyme 8.1E-13 0.578 0.692
GADD45A P24522 growth arrest and DNA damage inducible alpha 4.4E-02 0.526 0.769
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923
GSTT1 P30711 glutathione S-transferase theta 1 1.5E-04 0.393 0.923
HPGDS O60760 hematopoietic prostaglandin D synthase 1.8E-06 0.388 0.923
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923
POLH Q9Y253 DNA polymerase eta 3.5E-09 0.663 0.462
POLQ O75417 DNA polymerase theta Enzyme 1.3E-82 0.695 0.462
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
RAD54L Q92698 RAD54 like 2.4E-15 0.633 0.423
RECQL P46063 RecQ like helicase Enzyme 1.5E-20 0.615 0.615
RTEL1 Q9NZ71 regulator of telomere elongation helicase 1 Enzyme 8.9E-10 0.459 0.808
SLX4 Q8IY92 SLX4 structure-specific endonuclease subunit 1.6E-22 0.565 0.731
SULT1A1 P50225 sulfotransferase family 1A member 1 3.0E-11 0.554 0.769
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962