Disease: Hypertrophic obstructive cardiomyopathy
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
SCN10A Q9Y5Y9 sodium voltage-gated channel alpha subunit 10 Ion channel 9.9E-38 0.566 0.692
HCN4 Q9Y3Q4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 Ion channel 1.00 0.617 0.269
HDAC2 Q92769 histone deacetylase 2 Epigenetic regulator 1.00 0.476 0.846
RYR2 Q92736 ryanodine receptor 2 Ion channel 1.00 0.539 0.615
TTN Q8WZ42 titin Kinase 2.6E-96 0.470 0.885
CAVIN1 Q6NZI2 caveolae associated protein 1 Transcription factor 5.0E-03 0.559 0.654
MYBPC3 Q14896 myosin binding protein C3 8.0E-11 0.593 0.385
FLNC Q14315 filamin C 1.00 0.568 0.615
DSG2 Q14126 desmoglein 2 Cell adhesion 2.8E-10 0.601 0.692
CACNA1C Q13936 calcium voltage-gated channel subunit alpha1 C Ion channel 1.00 0.510 0.846
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885
ADAM17 P78536 ADAM metallopeptidase domain 17 1.00 0.453 0.808
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923
CAV3 P56539 caveolin 3 Enzyme modulator 5.5E-03 0.564 0.692
KCNQ1 P51787 potassium voltage-gated channel subfamily Q member 1 Ion channel 4.5E-08 0.485 0.769
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1.4E-06 0.320 0.885
TNNT2 P45379 troponin T2, cardiac type Cellular structure 2.0E-03 0.601 0.423
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962
CALCR P30988 calcitonin receptor G-protein coupled receptor 3.1E-09 0.464 0.846
AGTR1 P30556 angiotensin II receptor type 1 G-protein coupled receptor 5.3E-04 0.423 0.846
PLN P26678 phospholamban 0.45 0.595 0.577
TNNI3 P19429 troponin I3, cardiac type Cellular structure 9.6E-02 0.520 0.769