Disease: Heroin Dependence
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ADH1B P00325 alcohol dehydrogenase 1B (class I), beta polypeptide Enzyme 9.9E-07 0.502 0.846
ALDH2 P05091 aldehyde dehydrogenase 2 family member Enzyme 3.4E-10 0.457 0.885
ANKK1 Q8NFD2 ankyrin repeat and kinase domain containing 1 Kinase 7.4E-12 0.604 0.462
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923
CLOCK O15516 clock circadian regulator 1.00 0.463 0.885
CNR1 P21554 cannabinoid receptor 1 G-protein coupled receptor 0.51 0.446 0.808
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923
CRHR1 P34998 corticotropin releasing hormone receptor 1 3.8E-05 0.517 0.769
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846
DRD3 P35462 dopamine receptor D3 G-protein coupled receptor 2.4E-03 0.529 0.692
DRD4 P21917 dopamine receptor D4 G-protein coupled receptor 9.3E-09 0.517 0.577
FAAH O00519 fatty acid amide hydrolase 4.4E-11 0.545 0.692
FKBP5 Q13451 FKBP prolyl isomerase 5 Enzyme 0.73 0.524 0.769
GABRA2 P47869 gamma-aminobutyric acid type A receptor subunit alpha2 Ion channel 1.00 0.641 0.346
GABRB3 P28472 gamma-aminobutyric acid type A receptor subunit beta3 Ion channel 0.95 0.546 0.615
HTR1B P28222 5-hydroxytryptamine receptor 1B G-protein coupled receptor 0.19 0.551 0.769
HTR2A P28223 5-hydroxytryptamine receptor 2A G-protein coupled receptor 0.51 0.473 0.846
LEP P41159 leptin 0.46 0.349 0.846
MAOA P21397 monoamine oxidase A 1.00 0.465 0.769
MPDZ O75970 multiple PDZ domain crumbs cell polarity complex component 5.8E-38 0.638 0.500
OPRM1 P35372 opioid receptor mu 1 G-protein coupled receptor 7.9E-11 0.457 0.808
PDYN P01213 prodynorphin Signaling 1.7E-04 0.535 0.577
PENK P01210 proenkephalin Signaling 2.1E-04 0.560 0.808
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885