Disease: Hereditary Breast and Ovarian Cancer Syndrome
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846
CDH1 P12830 cadherin 1 0.15 0.401 0.808
CDK2 P24941 cyclin dependent kinase 2 Kinase 0.61 0.456 0.692
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
COL11A2 P13942 collagen type XI alpha 2 chain 0.70 0.435 0.846
EPHA3 P29320 EPH receptor A3 Kinase 1.2E-05 0.497 0.692
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
FAP Q12884 fibroblast activation protein alpha Enzyme 1.9E-28 0.496 0.808
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
PARP1 P09874 poly(ADP-ribose) polymerase 1 3.3E-04 0.389 0.923
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
RAD51B O15315 RAD51 paralog B 2.1E-15 0.556 0.769
RAD52 P43351 RAD52 homolog, DNA repair protein Nucleic acid binding 7.1E-11 0.610 0.654
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962