Source: CLINVAR ×
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
CREBBP Q92793 CREB binding protein 1.00 0.428 0.808
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1 2.6E-12 0.424 0.808
CYP21A2 P08686 cytochrome P450 family 21 subfamily A member 2 2.6E-04 0.525 0.769
SF3B2 Q13435 splicing factor 3b subunit 2 1.00 0.780 0.308
CASC11 cancer susceptibility 11 0.641 0.577
CNOT9 Q92600 CCR4-NOT transcription complex subunit 9 0.99 0.769 0.192
PPP6C O00743 protein phosphatase 6 catalytic subunit 0.86 0.729 0.231
BCL2L12 Q9HB09 BCL2 like 12 3.8E-09 0.606 0.654
STK19 P49842 serine/threonine kinase 19 6.7E-09 0.691 0.500
KNSTRN Q9Y448 kinetochore localized astrin (SPAG5) binding protein 2.1E-06 0.729 0.500
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 0.68 0.420 0.885
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808
FBXW7 Q969H0 F-box and WD repeat domain containing 7 Enzyme modulator 1.00 0.465 0.808
GNA11 P29992 G protein subunit alpha 11 Enzyme modulator 0.89 0.563 0.731
RAC1 P63000 Rac family small GTPase 1 Enzyme modulator 0.76 0.429 0.962
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885
B2M P61769 beta-2-microglobulin Immune response 0.56 0.447 0.846
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923