Disease: Marfan Syndrome
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
COL1A1 P02452 collagen type I alpha 1 chain 1.00 0.430 0.808
COL3A1 P02461 collagen type III alpha 1 chain 1.00 0.477 0.808
SMAD2 Q15796 SMAD family member 2 Transcription factor 1.00 0.456 0.808
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962
LOX P28300 lysyl oxidase 0.99 0.447 0.846
TGFB3 P10600 transforming growth factor beta 3 Signaling 0.99 0.498 0.808
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923
TGFBR1 P36897 transforming growth factor beta receptor 1 Kinase 0.85 0.451 0.885
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962
SMAD3 P84022 SMAD family member 3 Transcription factor 0.80 0.415 0.923
TIMP2 P16035 TIMP metallopeptidase inhibitor 2 Enzyme modulator 0.79 0.425 0.846
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
DCN P07585 decorin 0.31 0.457 0.808
TGFBR2 P37173 transforming growth factor beta receptor 2 Kinase 0.13 0.413 0.846
COX8A P10176 cytochrome c oxidase subunit 8A Enzyme 0.12 0.400 0.846
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885
LTBP2 Q14767 latent transforming growth factor beta binding protein 2 Calcium-binding protein 7.4E-04 0.572 0.692
AGTR1 P30556 angiotensin II receptor type 1 G-protein coupled receptor 5.3E-04 0.423 0.846
SLC33A1 O00400 solute carrier family 33 member 1 Transporter 9.9E-05 0.529 0.769
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885
TGFBI Q15582 transforming growth factor beta induced Signaling 6.0E-08 0.484 0.769