Disease: Hyperlipoproteinemia Type IIa
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962
REN P00797 renin Enzyme 2.4E-07 0.370 0.923
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885
APOA1 P02647 apolipoprotein A1 5.5E-04 0.429 0.885
LPA P08519 lipoprotein(a) Enzyme 6.6E-89 0.444 0.769
GLB1 P16278 galactosidase beta 1 Enzyme 7.9E-10 0.448 0.808
LDLR P01130 low density lipoprotein receptor 9.8E-24 0.449 0.885
APOB P04114 apolipoprotein B 1.9E-16 0.453 0.808
ABCA1 O95477 ATP binding cassette subfamily A member 1 Transporter 1.5E-13 0.467 0.846
LPL P06858 lipoprotein lipase Enzyme 1.3E-09 0.474 0.808
CAD P27708 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Enzyme 1.00 0.482 0.846
LRP1 Q07954 LDL receptor related protein 1 1.00 0.482 0.769
PCSK9 Q8NBP7 proprotein convertase subtilisin/kexin type 9 Enzyme 2.7E-17 0.482 0.808
IL2RB P14784 interleukin 2 receptor subunit beta Receptor 0.29 0.491 0.846
CETP P11597 cholesteryl ester transfer protein 1.2E-23 0.512 0.731
NPC1 O15118 NPC intracellular cholesterol transporter 1 Transporter 6.5E-06 0.518 0.692
PLA2G15 Q8NCC3 phospholipase A2 group XV Enzyme 0.38 0.520 0.769
ATP2A2 P16615 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Transporter 1.00 0.529 0.808
HMGCR P04035 3-hydroxy-3-methylglutaryl-CoA reductase 1.00 0.529 0.692
APOC3 P02656 apolipoprotein C3 1.0E-02 0.531 0.731
SLC22A3 O75751 solute carrier family 22 member 3 Transporter 7.8E-10 0.531 0.846