Disease: HER2 gene amplification
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ARID1A O14497 AT-rich interaction domain 1A 1.00 0.455 0.846
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962
GAST P01350 gastrin 2.7E-03 0.485 0.808
GRB7 Q14451 growth factor receptor bound protein 7 Receptor 1.4E-06 0.603 0.462
KRT20 P35900 keratin 20 9.1E-11 0.388 0.846
KDR P35968 kinase insert domain receptor Kinase 1.00 0.378 0.885
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
MKI67 P46013 marker of proliferation Ki-67 1.3E-28 0.431 0.808
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923
NCOA3 Q9Y6Q9 nuclear receptor coactivator 3 Kinase 0.54 0.522 0.654
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
PGR P06401 progesterone receptor Nuclear receptor 5.1E-02 0.426 0.885
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962
RARB P10826 retinoic acid receptor beta Nuclear receptor 1.00 0.478 0.846
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962