Disease: HER2 gene amplification
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ARID1A O14497 AT-rich interaction domain 1A 1.00 0.455 0.846
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923
GAST P01350 gastrin 2.7E-03 0.485 0.808
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
PGR P06401 progesterone receptor Nuclear receptor 5.1E-02 0.426 0.885
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885
RARB P10826 retinoic acid receptor beta Nuclear receptor 1.00 0.478 0.846
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962
KRT20 P35900 keratin 20 9.1E-11 0.388 0.846
KDR P35968 kinase insert domain receptor Kinase 1.00 0.378 0.885
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
MKI67 P46013 marker of proliferation Ki-67 1.3E-28 0.431 0.808
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
GRB7 Q14451 growth factor receptor bound protein 7 Receptor 1.4E-06 0.603 0.462