Disease: Parkinsonism with favorable response to dopaminergic medication
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ATP13A2 Q9NQ11 ATPase cation transporting 13A2 9.0E-09 0.566 0.577
DNAJC13 O75165 DnaJ heat shock protein family (Hsp40) member C13 1.00 0.682 0.577
EIF4G1 Q04637 eukaryotic translation initiation factor 4 gamma 1 Nucleic acid binding 1.00 0.553 0.808
FBXO7 Q9Y3I1 F-box protein 7 5.8E-07 0.650 0.769
GBA P04062 glucosylceramidase beta 1.4E-06 0.500 0.808
GCH1 P30793 GTP cyclohydrolase 1 Enzyme 0.90 0.511 0.846
GIGYF2 Q6Y7W6 GRB10 interacting GYF protein 2 1.00 0.711 0.269
HTRA2 O43464 HtrA serine peptidase 2 3.6E-03 0.542 0.692
LRRK2 Q5S007 leucine rich repeat kinase 2 Kinase 2.6E-30 0.510 0.808
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923
PARK7 Q99497 Parkinsonism associated deglycase Enzyme 0.75 0.535 0.808
PLA2G6 O60733 phospholipase A2 group VI Enzyme modulator 2.5E-10 0.476 0.846
POLG P54098 DNA polymerase gamma, catalytic subunit Enzyme 2.1E-09 0.457 0.846
SNCA P37840 synuclein alpha Transporter 0.88 0.427 0.885
TAF1 P21675 TATA-box binding protein associated factor 1 Kinase 1.00 0.581 0.808
TH P07101 tyrosine hydroxylase 1.7E-06 0.462 0.885
TK2 O00142 thymidine kinase 2 Kinase 3.9E-07 0.585 0.615
VPS35 Q96QK1 VPS35 retromer complex component Transporter 0.97 0.656 0.500