Disease: Autosomal Dominant Juvenile Parkinson Disease
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
LRRK2 Q5S007 leucine rich repeat kinase 2 Kinase 2.6E-30 0.510 0.808
PINK1 Q9BXM7 PTEN induced kinase 1 Kinase 1.9E-10 0.516 0.769
POLG P54098 DNA polymerase gamma, catalytic subunit Enzyme 2.1E-09 0.457 0.846
ATP13A2 Q9NQ11 ATPase cation transporting 13A2 9.0E-09 0.566 0.577
DDC P20711 dopa decarboxylase 3.8E-08 0.535 0.769
PRL P01236 prolactin Signaling 2.9E-07 0.406 0.885
PRKN O60260 parkin RBR E3 ubiquitin protein ligase Enzyme 6.9E-07 0.431 0.846
GSR P00390 glutathione-disulfide reductase Enzyme 1.3E-06 0.494 0.846
GBA P04062 glucosylceramidase beta 1.4E-06 0.500 0.808
TH P07101 tyrosine hydroxylase 1.7E-06 0.462 0.885
PDYN P01213 prodynorphin Signaling 1.7E-04 0.535 0.577
PARP1 P09874 poly(ADP-ribose) polymerase 1 3.3E-04 0.389 0.923
HTRA2 O43464 HtrA serine peptidase 2 3.6E-03 0.542 0.692
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923
PNOC Q13519 prepronociceptin Signaling 1.5E-02 0.603 0.577
SLC18A2 Q05940 solute carrier family 18 member A2 Transporter 7.6E-02 0.554 0.769
DCTN1 Q14203 dynactin subunit 1 Chaperone 8.4E-02 0.597 0.500
GDNF P39905 glial cell derived neurotrophic factor Signaling 0.20 0.434 0.885
ALDH1A2 O94788 aldehyde dehydrogenase 1 family member A2 Enzyme 0.36 0.578 0.692
PRKRA O75569 protein activator of interferon induced protein kinase EIF2AK2 Kinase 0.42 0.579 0.615
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846
PARK7 Q99497 Parkinsonism associated deglycase Enzyme 0.75 0.535 0.808
NGF P01138 nerve growth factor Signaling 0.82 0.391 0.885
SNCA P37840 synuclein alpha Transporter 0.88 0.427 0.885
ALDH1A1 P00352 aldehyde dehydrogenase 1 family member A1 Enzyme 0.95 0.460 0.846