Disease: Hereditary Nonpolyposis Colorectal Cancer
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
MIR148A microRNA 148a 0.506 0.846
ARID1A O14497 AT-rich interaction domain 1A 1.00 0.455 0.846
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
IGF2R P11717 insulin like growth factor 2 receptor Receptor 1.00 0.518 0.731
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846
EPCAM P16422 epithelial cell adhesion molecule 1.3E-07 0.451 0.885
MGMT P16455 O-6-methylguanine-DNA methyltransferase 1.2E-07 0.412 0.885
MSH3 P20585 mutS homolog 3 Nucleic acid binding 7.4E-31 0.474 0.769
MRC1 P22897 mannose receptor C-type 1 0.94 0.413 0.846
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962
TGFBR2 P37173 transforming growth factor beta receptor 2 Kinase 0.13 0.413 0.846
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808