Disease: Hypercholesterolemia, Familial
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ACCS Q96QU6 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Enzyme 9.0E-07 0.522 0.731
ACSS2 Q9NR19 acyl-CoA synthetase short chain family member 2 Enzyme 1.1E-13 0.506 0.808
ALOX5 P09917 arachidonate 5-lipoxygenase Enzyme 1.2E-06 0.447 0.885
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962
F3 P13726 coagulation factor III, tissue factor Receptor 1.9E-02 0.415 0.846
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962
IL6 P05231 interleukin 6 0.32 0.248 0.962
KDR P35968 kinase insert domain receptor Kinase 1.00 0.378 0.885
LDLR P01130 low density lipoprotein receptor 9.8E-24 0.449 0.885
LINC01194 long intergenic non-protein coding RNA 1194 0.470 0.769
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923
MPO P05164 myeloperoxidase Enzyme 7.1E-15 0.377 0.923
PLA2G15 Q8NCC3 phospholipase A2 group XV Enzyme 0.38 0.520 0.769
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885
SDC2 P34741 syndecan 2 Extracellular structure 0.40 0.536 0.808
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885
SLC2A1 P11166 solute carrier family 2 member 1 Transporter 0.99 0.388 0.808
SMARCA4 P51532 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Epigenetic regulator 1.00 0.450 0.885
SP1 P08047 Sp1 transcription factor Nucleic acid binding 1.00 0.493 0.769
STAT1 P42224 signal transducer and activator of transcription 1 Nucleic acid binding 1.00 0.399 0.885