Disease: Familial Alzheimer Disease (FAD)
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
PICALM Q13492 phosphatidylinositol binding clathrin assembly protein Transporter 1.00 0.592 0.538
TOMM40 O96008 translocase of outer mitochondrial membrane 40 Transporter 0.99 0.590 0.538
APOC1 P02654 apolipoprotein C1 0.22 0.581 0.577
NRGN Q92686 neurogranin 0.48 0.608 0.615
PYY P10082 peptide YY Signaling 1.2E-02 0.588 0.615
PSEN2 P49810 presenilin 2 Enzyme 5.4E-04 0.550 0.654
SUCLA2 Q9P2R7 succinate-CoA ligase ADP-forming subunit beta Enzyme 2.3E-03 0.566 0.654
ITM2B Q9Y287 integral membrane protein 2B 0.63 0.617 0.654
ATP5F1A P25705 ATP synthase F1 subunit alpha Transporter 1.00 0.604 0.731
SUMO1 P63165 small ubiquitin like modifier 1 0.86 0.533 0.731
NEFL P07196 neurofilament light 0.488 0.769
TREM2 Q9NZC2 triggering receptor expressed on myeloid cells 2 3.3E-09 0.519 0.769
C9orf72 Q96LT7 C9orf72-SMCR8 complex subunit 1.1E-06 0.496 0.769
NOTCH3 Q9UM47 notch receptor 3 0.41 0.435 0.808
CDK5R1 Q15078 cyclin dependent kinase 5 regulatory subunit 1 Enzyme modulator 0.91 0.529 0.808
EIF2AK3 Q9NZJ5 eukaryotic translation initiation factor 2 alpha kinase 3 Kinase 2.8E-03 0.501 0.808
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846
CTSD P07339 cathepsin D Enzyme 9.2E-04 0.478 0.846
ERBB4 Q15303 erb-b2 receptor tyrosine kinase 4 Kinase 1.00 0.455 0.846
GSK3B P49841 glycogen synthase kinase 3 beta Kinase 0.96 0.430 0.846
LEP P41159 leptin 0.46 0.349 0.846
NPY P01303 neuropeptide Y Signaling 0.14 0.447 0.846
PSEN1 P49768 presenilin 1 Enzyme 0.97 0.469 0.846
ACHE P22303 acetylcholinesterase (Cartwright blood group) Enzyme 1.00 0.445 0.885
CLU P10909 clusterin 7.8E-05 0.426 0.885