Disease: Amyotrophic Lateral Sclerosis, Familial
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846
ATXN2 Q99700 ataxin 2 Nucleic acid binding 0.85 0.482 0.808
C9orf72 Q96LT7 C9orf72-SMCR8 complex subunit 1.1E-06 0.496 0.769
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923
CHCHD10 Q8WYQ3 coiled-coil-helix-coiled-coil-helix domain containing 10 5.4E-06 0.623 0.462
CLU P10909 clusterin 7.8E-05 0.426 0.885
CTSD P07339 cathepsin D Enzyme 9.2E-04 0.478 0.846
DCTN1 Q14203 dynactin subunit 1 Chaperone 8.4E-02 0.597 0.500
DECR1 Q16698 2,4-dienoyl-CoA reductase 1 Enzyme 4.5E-14 0.426 0.885
FUS P35637 FUS RNA binding protein Nucleic acid binding 1.00 0.470 0.846
GFAP P14136 glial fibrillary acidic protein 1.5E-06 0.421 0.885
GNE Q9Y223 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Enzyme 2.5E-16 0.610 0.692
GRIA3 P42263 glutamate ionotropic receptor AMPA type subunit 3 Ion channel 1.00 0.566 0.692
HNRNPA1 P09651 heterogeneous nuclear ribonucleoprotein A1 1.00 0.529 0.885
IGFALS P35858 insulin like growth factor binding protein acid labile subunit Receptor 5.4E-11 0.511 0.846
INA Q16352 internexin neuronal intermediate filament protein alpha 1.5E-08 0.633 0.500
LAMP1 P11279 lysosomal associated membrane protein 1 Transporter 0.87 0.542 0.769
LINC01672 long intergenic non-protein coding RNA 1672 0.462 0.846
MAK16 Q9BXY0 MAK16 homolog 0.96 0.566 0.615
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923
MATR3 P43243 matrin 3 1.00 0.631 0.538
MSMB P08118 microseminoprotein beta Signaling 1.6E-02 0.498 0.846
NEFH P12036 neurofilament heavy 2.7E-12 0.588 0.769
OPTN Q96CV9 optineurin 5.9E-18 0.548 0.808
PFN1 P07737 profilin 1 0.73 0.565 0.769