Disease: Hereditary Malignant Neoplasm
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
BRCA3 breast cancer 3 0.705 0.269
XRCC2 O43543 X-ray repair cross complementing 2 4.0E-07 0.512 0.731
NBN O60934 nibrin Nucleic acid binding 2.2E-16 0.467 0.808
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885
PARP1 P09874 poly(ADP-ribose) polymerase 1 3.3E-04 0.389 0.923
CDH1 P12830 cadherin 1 0.15 0.401 0.808
COL11A2 P13942 collagen type XI alpha 2 chain 0.70 0.435 0.846
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962
TGFBR1 P36897 transforming growth factor beta receptor 1 Kinase 0.85 0.451 0.885
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
MRE11 P49959 MRE11 homolog, double strand break repair nuclease 1.3E-12 0.527 0.808
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731
BLM P54132 BLM RecQ like helicase 1.5E-15 0.535 0.808
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
MDM2 Q00987 MDM2 proto-oncogene Nucleic acid binding 1.00 0.362 0.846