Disease: Severe hereditary factor VIII deficiency disease
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ABO P16442 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Enzyme 0.427 0.885
COX8A P10176 cytochrome c oxidase subunit 8A Enzyme 0.12 0.400 0.846
CPB2 Q96IY4 carboxypeptidase B2 Enzyme 2.7E-17 0.536 0.846
F10 P00742 coagulation factor X Enzyme 2.3E-06 0.493 0.769
F2 P00734 coagulation factor II, thrombin Enzyme 1.1E-03 0.415 0.885
F3 P13726 coagulation factor III, tissue factor Receptor 1.9E-02 0.415 0.846
F5 P12259 coagulation factor V Enzyme 5.9E-15 0.441 0.846
F8 P00451 coagulation factor VIII Enzyme 1.00 0.542 0.769
F9 P00740 coagulation factor IX Enzyme 1.00 0.465 0.885
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885
PROC P04070 protein C, inactivator of coagulation factors Va and VIIIa Enzyme 1.9E-05 0.504 0.808
TFPI P10646 tissue factor pathway inhibitor Enzyme modulator 0.25 0.486 0.808
THBD P07204 thrombomodulin 5.4E-02 0.457 0.769
VWF P04275 von Willebrand factor Enzyme modulator 3.2E-25 0.408 0.885