Disease: Turcot syndrome (disorder)
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
MSH3 P20585 mutS homolog 3 Nucleic acid binding 7.4E-31 0.474 0.769
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923
FAP Q12884 fibroblast activation protein alpha Enzyme 1.9E-28 0.496 0.808
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808
PMS1 P54277 PMS1 homolog 1, mismatch repair system component Nucleic acid binding 1.3E-17 0.569 0.654
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
MRC1 P22897 mannose receptor C-type 1 0.94 0.413 0.846
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962
NF2 P35240 neurofibromin 2 1.00 0.468 0.885