Source: CLINVAR ×
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
FBXO11 Q86XK2 F-box protein 11 Enzyme 1.00 0.604 0.692
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
MAP3K1 Q13233 mitogen-activated protein kinase kinase kinase 1 Kinase 1.00 0.538 0.731
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846
RRAS2 P62070 RAS related 2 Enzyme modulator 0.97 0.656 0.500
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
OPCML Q14982 opioid binding protein/cell adhesion molecule like 0.23 0.606 0.654
CDH1 P12830 cadherin 1 0.15 0.401 0.808
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
MRPS18C Q9Y3D5 mitochondrial ribosomal protein S18C Nucleic acid binding 8.8E-05 0.890 0.154
PAK6 Q9NQU5 p21 (RAC1) activated kinase 6 4.3E-05 0.729 0.385
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731
PRKN O60260 parkin RBR E3 ubiquitin protein ligase Enzyme 6.9E-07 0.431 0.846
ABRAXAS1 Q6UWZ7 abraxas 1, BRCA1 A complex subunit 5.1E-07 0.760 0.269
XRCC2 O43543 X-ray repair cross complementing 2 4.0E-07 0.512 0.731
CHEK1 O14757 checkpoint kinase 1 Kinase 3.1E-08 0.492 0.808
RAD51D O75771 RAD51 paralog D 1.1E-09 0.674 0.385
BUB1B O60566 BUB1 mitotic checkpoint serine/threonine kinase B Kinase 7.0E-10 0.502 0.808
MRE11 P49959 MRE11 homolog, double strand break repair nuclease 1.3E-12 0.527 0.808
RAD51C O43502 RAD51 paralog C 6.2E-14 0.533 0.692
C11orf65 Q8NCR3 chromosome 11 open reading frame 65 2.0E-14 0.670 0.462