Source: CLINVAR ×
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ABRAXAS1 Q6UWZ7 abraxas 1, BRCA1 A complex subunit 5.1E-07 0.760 0.269
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846
BARD1 Q99728 BRCA1 associated RING domain 1 1.4E-24 0.597 0.538
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846
BUB1B O60566 BUB1 mitotic checkpoint serine/threonine kinase B Kinase 7.0E-10 0.502 0.808
BUB1B-PAK6 Q9NQU5 BUB1B-PAK6 readthrough 0.805 0.269
CDH1 P12830 cadherin 1 0.15 0.401 0.808
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
CHEK1 O14757 checkpoint kinase 1 Kinase 3.1E-08 0.492 0.808
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808
C11orf65 Q8NCR3 chromosome 11 open reading frame 65 2.0E-14 0.670 0.462
CYTB P00156 cytochrome b 0.529 0.808
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
FBXO11 Q86XK2 F-box protein 11 Enzyme 1.00 0.604 0.692
FANCM Q8IYD8 FA complementation group M Enzyme 2.4E-15 0.543 0.731
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
MRPS18C Q9Y3D5 mitochondrial ribosomal protein S18C Nucleic acid binding 8.8E-05 0.890 0.154
MAP3K1 Q13233 mitogen-activated protein kinase kinase kinase 1 Kinase 1.00 0.538 0.731
MRE11 P49959 MRE11 homolog, double strand break repair nuclease 1.3E-12 0.527 0.808
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731
NBN O60934 nibrin Nucleic acid binding 2.2E-16 0.467 0.808